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Application of exogenous MPA and hMG in preparing animal model drugs

An animal model, exogenous technology, applied in the direction of pharmaceutical formulations, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problem of no reports of drugs for ovulation-stimulating animal models, and achieve stable biological characteristics. , the effect of rapid development and easy feeding

Inactive Publication Date: 2018-05-04
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] So far, there is no report on the drug of animal model of ovulation induction in high progesterone state

Method used

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  • Application of exogenous MPA and hMG in preparing animal model drugs
  • Application of exogenous MPA and hMG in preparing animal model drugs
  • Application of exogenous MPA and hMG in preparing animal model drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] Adopt the medicine of MPA and hMG to carry out the construction method of the animal model of hyperovulation under a kind of high progesterone state, flow process is as follows figure 1 As shown, it is achieved through the following steps:

[0034] (1) Select 6-week-old female mice, observe the sexual cycle at 8:00 a.m. every day, observe two sexual cycles continuously, and select mice with normal sexual cycles as the object of model construction;

[0035] (2) The mice selected in the step (1) are randomly divided into experimental group, normal control group, negative control group and positive control group; the MPA sheet is ground into powder, and the MPA of 30mg / ml is mixed with salad oil Suspension, hMG powder is formulated into the hMG liquid of 20IU / ml at the same time, (the daily feeding amount of MPA suspension and hMG liquid), at 8:00 early every day, gavage continuously for 5 days; normal control The same dose of salad oil in the control group was given to t...

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Abstract

The invention provides an application of the combined use of exogenous MPA and hMG in preparing animal model drugs capable of promoting ovulation under a high-progestogen state, wherein the dosage ofMPA is 2.8-3.2mg / kg / day, and the dosage of hMG is 4.5-5.5IU / kg / day. The invention aims at filling a blank of animal model drugs capable of promoting ovulation under the high-progestogen state in the prior; and a necessary experimental basis is provided for improving the curative effect and the action mechanism of an ovulation-promoting solution under the high-progestogen state.

Description

technical field [0001] The invention relates to the field of animal model construction of diseases, in particular to the application of combined use of exogenous MPA and hMG in the preparation of medicaments for animal models of ovulation induction under high progesterone status. Background technique [0002] With the change of people's lifestyle, infertility has become the third largest disease in the world after cancer and cardiovascular and cerebrovascular diseases. Infertility refers to not taking any contraceptive measures for one year, having normal sex life but no successful pregnancy, which is divided into male infertility and female infertility. At present, the prevalence rate of couples of childbearing age in my country is 12%-15%, leading to more and more infertile patients seeking assisted reproductive technology (ART) to conceive a new life. Controlled ovulation induction (COH) and in vitro fertilization / intraplasmic sperm injection (IVF / ICSI) are classic ART p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61K31/573
CPCA61K31/573A61K38/22A61K2300/00
Inventor 柴蔚然匡延平温晓薇
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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