Application of monomer hosenkoside A in preparing anti-tumor drugs or health care products

A technology of impatiens tetraol and antineoplastic drugs, applied in the application field of monomer impatiens tetraol A in the preparation of antineoplastic drugs or health products

Inactive Publication Date: 2018-05-08
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is the first research on the direct application of monomer impatiens tetraol A as an active ingredient of anti-A375 human malignant melanoma, anti-DLD-1 human colon adenocarcinoma and anti-HepG2 human liver cancer drugs or health products

Method used

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  • Application of monomer hosenkoside A in preparing anti-tumor drugs or health care products
  • Application of monomer hosenkoside A in preparing anti-tumor drugs or health care products
  • Application of monomer hosenkoside A in preparing anti-tumor drugs or health care products

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1 Preparation of Impatien Tetraol A

[0024] 1 kg of acute child powder was refluxed and extracted 4 times with a 70% ethanol aqueous solution, and the extraction time was 60, 45, 30, and 30 minutes. The extracts are combined, filtered, concentrated under reduced pressure to 6 times the mass of the medicinal materials, and then the medicinal liquid is obtained. The pH of the medicinal liquid is adjusted to about 6.0, the flow rate is 3 times the volume of the resin per hour, and the resin is washed through AB-8 macroporous resin. It is colorless, eluted with 80% ethanol with 6 times the volume of the resin, concentrated under reduced pressure to recover the ethanol, and dried at 105°C to obtain 60 g crude product of total saponins of Acuteko.

[0025] Take 60g of impatien terpene tetraol glycoside saponins and desorb with dichloromethane:methanol 5:1:0.1 as eluent, collect the product, absorb the product with ODS, and desorb with methanol:water 3:1 to obtain 0.2g of ...

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Abstract

The invention relates to application of monomer hosenkoside A in preparing anti-tumor drugs. Specifically, the invention provides new application of the monomer hosenkoside A, namely that the monomerhosenkoside A has a remarkable inhibiting effect on A375 human malignant melanoma cells and can be used for preparing drugs and health care products for resisting A375 human malignant melanoma, has aremarkable inhibiting effect on DLD-1 human colonic adenocarcinoma cells and can be used for preparing drugs and health care products for resisting DLD-1 human colonic adenocarcinoma, and has a remarkable inhibiting effect on HepG2 human hepatocellular carcinoma cells and can be used for preparing drugs and health care products for resisting HepG2 human hepatocellular carcinoma.

Description

Technical field [0001] The application of the compound of the present invention specifically relates to the application of the monomer impatien tetraol A in the preparation of anti-tumor drugs or health products, including the application in the preparation of anti-A375 human malignant melanoma drugs or health products, and the preparation of anti-DLD -1 Application in human colon adenocarcinoma drugs or health products and application in the preparation of anti-HepG2 human liver cancer drugs or health products. Background technique [0002] Impatiens, also known as Jinfenghuazi and Impatiens, is the dry mature seed of the impatiens genus Impatiens. It was first recorded in "Saving Famine" and is one of the traditional Chinese medicines in my country. The medicinal materials are oval, oblate or oblate. The fruits are harvested in summer and autumn when they are mature but not cracked. They are sun-dried, the seeds are rubbed out, and the peel and impurities are removed. They are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P35/00A23L33/11
CPCA61K31/7048A23L33/11A23V2002/00A23V2200/308A23V2250/2136
Inventor 李绪文吴谦金永日
Owner JILIN UNIV
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