Application of arginine in preparation of anticarcinogen as synergist of chemotherapeutic drug

A technology for anticancer drugs and chemotherapeutic drugs, applied in the field of biomedicine, can solve problems such as increasing the chemosensitivity of cisplatin, and achieve the effects of enhancing the inhibitory effect, reducing the dosage, and reducing adverse reactions

Inactive Publication Date: 2020-11-17
SHANXI UNIV
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Problems solved by technology

At present, there is no report on the effect of arginine combined with cisplatin on increasing the chemosensitivity of cisplatin

Method used

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  • Application of arginine in preparation of anticarcinogen as synergist of chemotherapeutic drug

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Embodiment Construction

[0017] The present invention will be further described in detail below in conjunction with specific embodiments. This embodiment is carried out on the premise of the technical solution of the present invention, and a detailed implementation manner and specific operation process are given, but the protection scope of the present invention is not limited to this embodiment.

[0018] Example Arginine combined with cisplatin inhibits HT29 human colon adenocarcinoma cell activity evaluation in vitro

[0019] The arginine described in this example was purchased from Beijing Suolaibao Technology Co., Ltd.; the cisplatin was purchased from Sigma; the HT29 human colon adenocarcinoma cells were purchased from the Cell Bank of the Chinese Academy of Sciences.

[0020] The anti-colon cancer effect evaluation method described in this example is the MTT method.

[0021] Relate to the specific scheme of MTT method in the present embodiment as follows:

[0022] Cisplatin and arginine were p...

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Abstract

The chemotherapeutic drug is cisplatin. The invention discloses application of arginine in preparation of an anticarcinogen as a synergist of a chemotherapeutic drug. An in-vitro cell experiment result shows that when the arginine and the cisplatin are used jointly, an inhibiting action on a human colonic adenocarcinoma cell HT29 can be improved remarkably, and a synergistic action can be achieved. Under the condition of the same inhibiting effect, the dosage of the cisplatin is lowered, and thus, potential adverse reactions of the cisplatin can be reduced effectively.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of arginine as a chemotherapeutic synergist in the preparation of anticancer drugs. Background technique [0002] Colon cancer is one of the most common malignant tumors, and its morbidity and mortality are increasing year by year. Since there is no exact etiology for colon cancer, the pathogenesis remains inconclusive. Most colon cancer patients have developed to the middle and late stages when they are diagnosed, and chemotherapy drugs are needed to inhibit tumor growth and prolong survival time. As a representative drug in the field of inorganic medicinal chemistry, cisplatin has been approved for use by the U.S. Food and Drug Administration (FDA) in 1978. Because of its broad anticancer spectrum and strong effect, it has been used for ovarian cancer and testicular cancer. It is one of the most widely clinically used broad-spectrum anticancer drugs for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K33/243A61P35/00A23L33/16A23L33/175
CPCA23V2002/00A61K31/198A23L33/16A23L33/175A61P35/00A61K33/243A61K2300/00A23V2200/308A23V2250/1622A23V2250/0606
Inventor 李震宇曹建华秦雪梅
Owner SHANXI UNIV
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