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Injectable bone repair material and preparation method thereof

A technology for bone repair and tooth matrix, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problems of instability, inability to be popularized, easy to cause rejection, etc., achieve good biocompatibility, and have osteoinductive activity , no immune rejection effect of osteoinductive activity

Inactive Publication Date: 2018-05-18
深圳市光明创博生物制品发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide an injectable bone repair material and its preparation method, aiming at solving the problems that the existing bone repair materials easily cause rejection, are unstable, and cannot be popularized and used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0055] (1) Weigh the permanent tooth, wash it 5 times with purified water, filter the water, add 3mol / L peracetic acid for disinfection, and soak for 2 hours; filter the solution, add purified water to wash 3-5 times, filter the water , add 5mol / L calcium bicarbonate solution, soak and stir for 4 hours; then add 5mol / L sodium sulfite solution for reduction, stir for 3 hours, and then soak for 5 hours.

[0056] (2) Filter off the solution, add purified water to wash 5 times, and filter off the water; mechanically pulverize to obtain solid particles with a particle size of 250 μm.

[0057] (3) Add 0.5 mol / L hydrochloric acid solution to the above solid particles, stir and soak for 24 hours (24 hours in total), filter off the solution, add purified water to wash 5 times, filter off the water, and obtain a decalcified human tooth matrix material.

[0058] (4) Put the above-mentioned decalcified human tooth matrix material into a vacuum freeze dryer, and set the vacuum degree to 35...

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Abstract

The invention discloses an injectable bone repair material and a preparation method thereof. The preparation method comprises the following steps: performing reduction, pulverization and decalcification treatment on permanent teeth to obtain a decalcified human tooth matrix material, and drying and sterilizing to prepare a decalcified human tooth matrix material freeze-drying agent; dissolving collagen powder into a solvent and preparing a collagen solution; and mixing the decalcified human tooth matrix material freeze-drying agent and the collagen solution uniformly and preparing the injectable bone repair material. The injectable bone repair material prepared by the method has high biocompatibility, avoids immunological rejection, has bone induction activity, can serve as irregular bonerepair, is suitable for closed operation treatment and has wide clinical market prospect.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an injectable bone repair material and a preparation method thereof. Background technique [0002] At present, bone defects caused by trauma, infection, tumor, etc. are a key factor that endangers human health and affect people's normal living standards, and most of them cannot heal by themselves and need bone transplantation. Since the American scholar Urist discovered bone morphogenetic protein (BMP) and put forward the theory of osteoinduction in the 1960s, people have conducted a lot of research on BMP and proposed a series of materials for bone grafting. Among them, autologous bone graft is currently recognized as the most effective bone graft material, which has good biocompatibility, non-immunogenicity and osteoinductivity; However, it cannot be transplanted on a large scale, so its clinical application is limited. In addition, allograft bone and xenograft bone can also ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/24A61L27/50
CPCA61L27/24A61L27/3608A61L27/50A61L2430/02C08L89/00
Inventor 毕晓寰
Owner 深圳市光明创博生物制品发展有限公司
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