Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A stabilized gel for aiding swallowing of solid oral medications

A technology for solid pharmaceutical preparations and gels, used in drug delivery, pharmaceutical formulations, liquid delivery, etc., can solve problems such as product quality changes, affecting appearance, etc., and achieve the effects of improving water-holding performance, rapid disintegration performance, and improving taste.

Active Publication Date: 2021-06-01
JIANGSU QIRUI MEDICINE TECH CO LTD
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The gel secretes liquid due to volume shrinkage. This water separation phenomenon not only affects the appearance, but also easily causes changes in product quality

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A stabilized gel for aiding swallowing of solid oral medications
  • A stabilized gel for aiding swallowing of solid oral medications
  • A stabilized gel for aiding swallowing of solid oral medications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Element Amount added (wt%) agar 0.26％ Locust Bean Gum 0.04％ xanthan gum 0.15％ Erythritol 5.0％ Xylitol 5.0％ Distilled Glyceryl Monostearate 0.01％ concentrated orange juice 2.0％ citric acid 0.2％ Sodium citrate 0.16％ water add up to 100%

[0040] Mix agar, locust bean gum, xanthan gum, erythritol, and xylitol into water, heat to boil while stirring, stir to dissolve, add flavoring agent, etc., stir to dissolve. Boil for 5 minutes, pass through a 100-mesh sieve, and cool. After testing, the prepared gel has a gel strength of 27g / cm at 20°C 2 , the pH value is 3.6, the disintegration time limit is 2 minutes, and the water separation rate is 2.94%.

Embodiment 2

[0042] Element Amount added (wt%) agar 0.25％ Locust Bean Gum 0.02％ xanthan gum 0.1％ Erythritol 4.0％ Xylitol 4.0％ Distilled Glyceryl Monostearate 0.01％ cocoa powder 0.5％ Monk Fruit Powder 0.01％ citric acid 0.01％ water add up to 100%

[0043] Mix agar, xanthan gum, locust bean gum, erythritol, and xylitol into water, heat to boil while stirring, stir to dissolve, add flavoring agent, etc., stir to dissolve. Boil for 5 minutes, pass through a 100-mesh sieve, and cool. After testing, the prepared gel has a gel strength of 34g / cm at 20°C 2 , the pH value is 6.5, the disintegration time limit is 1 minute, and the water separation rate is 1.54%.

Embodiment 3

[0045]

[0046]

[0047] Mix agar, locust bean gum, xanthan gum, erythritol, and xylitol into water, heat to boil while stirring, stir to dissolve, add flavoring agent, etc., stir to dissolve. Boil for 5 minutes, pass through a 100-mesh sieve, and cool. After testing, the prepared gel has a gel strength of 38g / cm at 20°C 2 , the pH value is 3.7, the disintegration time limit is 2 minutes, and the water separation rate is 2.63%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a gel for assisting swallowing of oral solid pharmaceutical preparations, which belongs to the field of food and contains formula food for special medical purposes. When the gel of the present invention contains 0.25% to 0.35% agar by weight, the prepared gel for assisting swallowing oral solid pharmaceutical preparations has good lubricating, wrapping and taste-masking properties, as well as rapid disintegration and suitable The effect of gel strength can also significantly improve the water-holding performance of the gel, and achieve the unexpected technical effect of controlling the water separation rate of the gel to not exceed 10% by weight.

Description

technical field [0001] The invention provides a gel for assisting swallowing of oral solid pharmaceutical preparations, which is used for patients with dysphagia (including psychosis), belongs to the field of food, and includes formula food for special medical purposes. Background technique [0002] It is difficult for patients with dysphagia to administer oral drugs. In the long-term recovery process, oral drugs are the most important way of administration. There is no good clinical solution to the problem of how to administer oral drugs to patients with dysphagia. It urgently needs to be solved. And many oral pharmaceutical preparations have special tastes, such as pungent tastes such as bitter taste, sour, pungent, which are difficult for users to accept. Pharmaceutical preparations, especially solid pharmaceutical preparations with large tablet diameters, if swallowed directly with water without chewing, often cause foreign body sensation and discomfort in the throat, an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K9/06
CPCA61K9/0053A61K9/06A61K47/42
Inventor 吴明辉邱瑞宝邓钢马成华藏永春李加根赵荣庆
Owner JIANGSU QIRUI MEDICINE TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com