Nano sunscreen agent, preparation method, and application thereof

A technology of sunscreen and organic sunscreen, applied in the field of nano-sunscreen and its synthesis, can solve the problems of reducing the photoprotection performance of sunscreen, easy leakage of organic sunscreen, uneven product particles, etc., to reduce the possibility of dissolution and transdermal , Improve the light protection efficiency, the effect of large diffusion resistance

Active Publication Date: 2018-06-29
JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These natural polymers and synthetic polymers embed organic sunscreens, and the product particles are uneven and large, making the skin feel grainy during application, and will reduce the photoprotective performance of sunscreens. At the same time, the embedded organic sunscreens Easy to leak, further causing skin allergies and contact dermatitis and other problems

Method used

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  • Nano sunscreen agent, preparation method, and application thereof
  • Nano sunscreen agent, preparation method, and application thereof
  • Nano sunscreen agent, preparation method, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 cinnamate / ZIF-8 nano sunscreen

[0043]Weigh 1.8g of 4-methoxycinnamic acid-2-ethylhexyl ester (OMC) in a beaker, weigh 8.2g (100mmol) 2-methylimidazole into the beaker, add 200ml of methanol, stir to obtain a uniform color solution; another 3g (10mmol) Zn(NO 3 ) 2 6H 2 O in a beaker, add 200ml of methanol, stir to form a colorless solution, under strong stirring, quickly pour the zinc nitrate solution into the methanol solution of 2-methylimidazole and OMC, stir at 25°C for 2h, and centrifuge the milky white suspension , the resulting white precipitate was washed three times with methanol, and finally the white precipitate was dried at 40°C to obtain the OMC / ZIF-8 new nano-scale sunscreen. Its diameter is 50nm~100nm, and its specific surface area, pore volume and pore diameter are shown in Table 1 and figure 1 and Figure 13 shown. Its isotherm is as Figure 12 shown.

[0044] sample

ZIF-8

Example 1

Langm...

Embodiment 2

[0047] The preparation of embodiment 2 Avobenzone / ZIF-8 nano sunscreen

[0048] Weigh 1.0g of butylmethoxydibenzoylmethane (Avobenzone) into a beaker, weigh 2.05g (25mmol) of 2-methylimidazole into the beaker, add 200ml of ethanol, stir to obtain a uniform colorless solution; 3g (10mmol) Zn(NO 3 ) 2 6H 2 O in a beaker, add 200ml of ethanol, stir to form a colorless solution, under strong stirring, quickly pour the zinc nitrate solution into the ethanol solution of 2-methylimidazole and Avobenzone, stir at 20°C for 12h, and centrifuge the milky white suspension , the resulting white precipitate was washed three times with methanol, and finally the white precipitate was dried at 40°C to obtain the Avobenzone / ZIF-8 new nano-scale sunscreen.

Embodiment 3

[0049] The preparation of embodiment 3 Oxybenzone / ZIF-8 nano sunscreen

[0050] Weigh 2.5g of 2,2'-dihydroxy-4-methoxybenzophenone (Oxybenzone) into a beaker, weigh 8.2g (100mmol) of 2-methylimidazole into the beaker, add 200ml of isopropanol, and stir Obtain a uniform colorless solution; another 3g (10mmol) Zn(NO 3 ) 2 6H 2 O in a beaker, add 200ml of isopropanol, stir to form a colorless solution, under strong stirring, quickly pour the zinc nitrate solution into 2-methylimidazole and 2,2'-dihydroxy-4-methoxybenzophenone In isopropanol solution, stirred at 30°C for 48h, the milky white suspension was centrifuged, the resulting white precipitate was washed three times with methanol, and finally the white precipitate was dried at 40°C to obtain the Oxybenzone / ZIF-8 new nano-scale sunscreen.

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Abstract

The invention discloses a nano sunscreen agent, a preparation method, and an application thereof. The nano sunscreen agent includes a zeolite imidazate framework structure material and an organic sunscreen agent which is sealed in the framework material. The zeolite imidazate framework structure material coats the surface of the organic sunscreen agent. The nano sunscreen agent has gentle synthesis conditions and short reaction time, can effectively inhibit contact between the organic sunscreen agent and skin and reduce direct contact between the organic sunscreen agent and an active oxygen substance, ROS, generated after photo-activation and skin, so that a series of phototoxicities caused by transdermal absorption of the nano sunscreen agent is prevented. The product is a novel nano sunscreen agent material.

Description

technical field [0001] The invention belongs to the field of cosmetics and skin care products, and in particular relates to a novel biologically safe and efficient nano-sunscreen agent encapsulated by a zeolite imidazolate skeleton structure material and a synthesis method and application thereof. Background technique [0002] As we all know, the sun can provide the energy needed for life activities for the living things on the earth. However, ultraviolet rays in sunlight often cause a series of biological damage to organisms, such as erythema formation, immunosuppression, oxidative stress, photoaging, DNA and RNA damage, and skin cancer. Therefore more and more people pay attention to the protection of ultraviolet rays. At present, the additives used for skin care photoprotection mainly include inorganic sunscreens and organic sunscreens. Inorganic sunscreens mainly reduce the damage of ultraviolet rays to the skin through the reflection and scattering of ultraviolet rays...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/11A61K8/26A61K8/35A61K8/37A61K8/49A61Q17/04
CPCA61K8/11A61K8/26A61K8/35A61K8/37A61K8/4946A61K2800/413A61Q17/04
Inventor 骆丹徐丽贤
Owner JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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