Zein-based nanometer sunscreen agent, and preparation method and application thereof

A technology of zein and zein, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve safety problems, reduce the photoprotective performance of organic sunscreens, etc., achieve high encapsulation efficiency, reduce Possibility of dissolution and transdermal, effects of reducing phototoxicity and photooxidative toxicity

Active Publication Date: 2018-11-16
JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these hydrophilic natural polymers need to be chemically cross-linked after encapsulation to form a three-dimensional structure to reduce the leakage of embedded substances, and the residue of these chemical cross-linked substances will cause a series of safety problems
At the same time, there is incompatibility between hydrophilic natural polymers and hydrophobic organic sunscreens on the molecular scale, thus greatly reducing the photoprotective performance of organic sunscreens

Method used

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  • Zein-based nanometer sunscreen agent, and preparation method and application thereof
  • Zein-based nanometer sunscreen agent, and preparation method and application thereof
  • Zein-based nanometer sunscreen agent, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The preparation of embodiment 1 cinnamate / Zein nano sunscreen

[0040] First, 2.5g of zein and 1g of 4-methoxycinnamic acid-2-ethylhexyl ester (OMC) were dissolved in 50ml of 80% ethanol aqueous solution, stirred at room temperature for 2h, and fully dissolved. Under the condition of stirring at 1000 rpm, the above mixed solution was slowly added dropwise to deionized water through a constant flow pump, and the dropwise addition was completed within 12 hours. After that, homogenized with a high-pressure homogenizer for 5 minutes, and the ethanol was removed by rotary evaporation, so that the compound was in the The concentration in the suspension reaches 1%. Centrifuge at 4000rpm for 10 minutes to remove large particles, and the obtained emulsion is the cinnamate / Zein nano sunscreen aqueous dispersion. The product looks like figure 1 As shown, the particle size is 100~200nm. Wherein the mass of OMC is 15% of the protein mass.

[0041] The light protection performanc...

Embodiment 2

[0043] The preparation of embodiment 2 Avobenzone / Zein nano sunscreen

[0044] Weigh 1.0g of butylmethoxydibenzoylmethane (Avobenzone) into a beaker, weigh 3g of zein into the beaker, add 50ml of ethanol aqueous solution with a mass concentration of 85%, and stir to obtain a uniform yellow transparent homogeneous solution; Under strong stirring, slowly add the ethanol aqueous solution of the above mixture into deionized water with a constant flow pump, and the dropwise addition is completed within 24 hours. The concentration in the suspension reaches 1%. Centrifuge at 4000rpm for 10 minutes to remove large particles, and the resulting emulsion is the Avobenzone / Zein nano-sunscreen aqueous dispersion. The obtained sample looks like figure 2 shown. Wherein the quality of Avobenzone is 20% of protein Zein quality.

Embodiment 3

[0045] The preparation of embodiment 3 Oxybenzone / ZIF-8 nano sunscreen

[0046] Weigh 5.6g of 2,2'-dihydroxy-4-methoxybenzophenone (Oxybenzone) into a beaker, weigh 10g of zein into the beaker, add 100ml of acetone aqueous solution with a mass concentration of 85%, and stir Obtain a uniform yellow transparent solution in 2 hours; under strong stirring, slowly add the ethanol aqueous solution of the above mixture into deionized water with a constant flow pump, and the addition is completed within 1 hour. After that, use a high-pressure homogenizer to homogenize for 10 minutes, and then spray Dry to obtain Oxybenzone / Zein nano sunscreen. Wherein the quality of Oxybenzone is 50% of protein Zein quality.

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Abstract

The invention discloses a zein-based nanometer sunscreen agent, and a preparation method and an application thereof. The nanometer sunscreen agent comprises zein and an organic sunscreen agent encapsulated by the zein, and the surface of the organic sunscreen agent is coated with the zein. The nanometer sunscreen agent has the advantages of mild synthesis conditions, short reaction time, effectiveness in inhibition of direct contact of the organic sunscreen agent with skins, reduction of direct contact of the organic sunscreen agent and reactive oxygen species (ROS) generated after light activation with skins, and inhibition of a series of phototoxicity caused by transdermal absorption, and is a novel nanometer sunscreen agent material.

Description

technical field [0001] The invention belongs to the field of cosmetics and skin care products, and in particular relates to a novel biologically safe and high-efficiency zein material-encapsulated nano-sunscreen and its synthesis method and application. Background technique [0002] As we all know, the sun can provide the energy needed for life activities for the living things on the earth. However, ultraviolet rays in sunlight often cause a series of biological damage to organisms, such as erythema formation, immunosuppression, oxidative stress, photoaging, DNA and RNA damage, and skin cancer. Therefore more and more people pay attention to the protection of ultraviolet rays. At present, the additives used for skin care photoprotection mainly include inorganic sunscreens and organic sunscreens. Inorganic sunscreens mainly reduce the damage of ultraviolet rays to the skin through the reflection and scattering of ultraviolet rays, while organic sunscreens mainly reduce the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/37A61K8/35A61Q17/04
CPCA61K8/35A61K8/37A61K8/645A61Q17/04
Inventor 骆丹徐丽贤
Owner JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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