Anti-cancer drug composition

An anti-cancer drug and composition technology, applied in the directions of drug combination, anti-tumor drug, pharmaceutical formulation, etc., can solve the problems of complex process, increase the utilization cost of SN-38 drug, etc., achieve simple ball milling process, increase anti-cancer effect, Activity enhancing effect

Active Publication Date: 2018-07-24
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Although the above prior art has achieved the technical effect of increasing the solubility of SN-38, the process is relatively complicated, which increases the cost of SN-38 drug utilization

Method used

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  • Anti-cancer drug composition

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preparation example Construction

[0024] (1) Preparation of anticancer drug composition and comparative example:

[0025] 1. Preparation of anticancer drug composition:

[0026] (1) Raw material preparation: take 100mg of 7-ethyl-10-hydroxycamptothecin and 10g of sodium glycyrrhetinate in the dark;

[0027] (2) Roller ball mill: Prepare 20 small steel balls of 4mm, 8mm, and 12mm each, put the raw materials and small steel balls into the drum and mix well, tighten the cover, set the speed at 20rpm, temperature at 25°C, and rotate for 24h.

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Abstract

The invention discloses an anti-cancer drug composition. The anti-cancer drug composition is characterized by being composed of 7-ethyl-10-hydroxycamptothecine and sodium glycyrrhetinate, and is prepared by the following method comprising the steps: (1) preparing raw materials: weighing 7-ethyl-10-hydroxycamptothecine and sodium glycyrrhetinate; and (2) ball-milling through a roller: performing ball-milling through the roller on 7-ethyl-10-hydroxycamptothecine and sodium glycyrrhetinate, wherein ball-milling rotation speed is 10-30 rpm, the temperature is 20-30 DEG C, and ball-milling time is12-36 hours. The anti-cancer drug composition disclosed by the invention is simple in preparation process, is free of pollution on environment, is suitable for large-scale production, remarkably improves solubility of 7-ethyl-10-hydroxycamptothecine, and has a very good anticancer effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an anticancer drug composition. Background technique [0002] 7-ethyl-10-hydroxycamptothecin (7-ethyl-10-hydroxycamptothecin, SN-38), is the biologically active metabolite of irinotecan hydrochloride (CPT-11). CPT-11 is an inactive prodrug, which is converted into an active metabolite SN-38 by carboxylesterase (CES) in plasma, small intestinal mucosa and liver in vivo. In 2000, FDA approved irinotecan as an anticancer drug for advanced colon cancer. First-line treatment drugs. But in fact, the anti-tumor activity of SN-38 is 100-1000 times that of CPT-11. After intravenous or oral administration of CPT-11, only a small part of CPT-11 is converted into SN-38, and the difference between different patients very big. The direct use of the active metabolite SN-38 of CPT-11 is mainly limited by its solubility. SN-38 is almost insoluble in water (1-3μg / ml), and insoluble in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P35/00A61K31/4745
CPCA61K31/4745A61K31/56A61K2300/00
Inventor 孙漩嵘祝大部
Owner ZHEJIANG UNIV OF TECH
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