Steroids non-depolarization muscle relaxant antagonistic pharmaceutical composition

A depolarization and composition technology, applied in the field of medicinal chemistry, can solve the problems of slow heart rate, blood pressure drop, inhibition, etc., and achieve the effect of reducing slow heart rate and reducing nausea

Inactive Publication Date: 2018-08-14
SUZHOU SCI&TECH TOWN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Antagonists of existing steroidal muscle relaxants may cause adverse symptoms such as nausea, vomiting, slow heart rate, and drop in blood pressure when ...

Method used

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  • Steroids non-depolarization muscle relaxant antagonistic pharmaceutical composition
  • Steroids non-depolarization muscle relaxant antagonistic pharmaceutical composition
  • Steroids non-depolarization muscle relaxant antagonistic pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 6-deoxysulfoxide α-amino acid derivative cyclodextrin: 0.25mg;

[0028] Metoclopramide: 7mg;

[0029] Angiotensin II: 0.2ng;

[0030] Anhydrous sodium acetate: 1mg;

[0031] Sodium bisulfite: 0.8mg;

[0032] Citric acid: 0.35mg;

[0033] pH: 3.3;

[0034] Dosage form: tablet.

Embodiment 2

[0036] 6-deoxysulfoxide α-amino acid derivative cyclodextrin: 0.3mg;

[0037] Metoclopramide: 5mg;

[0038] Angiotensin II: 0.1ng;

[0039] Anhydrous sodium acetate: 1.1mg;

[0040] Sodium bisulfite: 0.7mg;

[0041] Citric acid: 0.3mg;

[0042] pH: 3.0;

[0043] Dosage form: capsules.

Embodiment 3

[0045] 6-deoxysulfoxide α-amino acid derivative cyclodextrin: 0.4mg;

[0046] Metoclopramide: 9mg;

[0047] Angiotensin II: 0.1ng;

[0048] Anhydrous sodium acetate: 1.5mg;

[0049] Sodium bisulfite: 1.1 mg;

[0050] Citric acid: 0.4mg;

[0051] pH: 4.1;

[0052] Dosage form: powder.

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PUM

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Abstract

The invention discloses a steroids non-depolarization muscle relaxant antagonistic pharmaceutical composition. The composition comprises 6-deoxy alpha-amino acid derivative cyclodextrin, metoclopramide, angiotensin II, anhydrous sodium acetate, sodium bisulfate, and citric acid. The 6-deoxy alpha-amino acid derivative cyclodextrin is a main component of the pharmaceutical composition; metoclopramide is an antiemetic, anhydrous sodium acetate and sodium bisulfite are added for assisting, and are co-effected on a dopamine receptor in a medulla oblongata chemoreceptor trigger zone, so that a threshold of the chemoreceptor trigger zone is increased; the angiotensin II is one of vaso-excitor active substances, and whole body arteriole contraction and arterial blood pressure rise can be realized; and the adverse symptoms such as decreased heart rate and drop of blood pressure of the steroids muscle relaxant antagonistic pharmaceutical composition can be effectively solved while in use, the pharmaceutical composition realizes combined action, and the steroids non-depolarization muscle relaxant antagonistic pharmaceutical composition capable of effectively reducing vomit and reducing adverse symptoms such as blood pressure can be provided.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to an antagonist pharmaceutical composition of steroid non-depolarizing muscle relaxants. Background technique [0002] Muscle relaxants, also known as skeletal muscle relaxants or N2 choline receptor blockers, can selectively act on the N2 receptors on the motor nerve endplate membrane, blocking the transmission of nerve impulses to skeletal muscles, causing muscle, skeletal Muscle relaxation. But it has no sedative, anesthetic and analgesic effects. However, endotracheal intubation is not convenient during general anesthesia. Therefore, the use of muscle relaxants in clinical anesthesia has changed the need to obtain muscle relaxation by deepening general anesthesia to meet the requirements of surgery. At present, muscle relaxants have become an important adjuvant drug for general anesthesia, for rapid induction of endotracheal intubation and muscle relaxation during surgery. ...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61P1/08A61P9/06A61P9/02A61P21/02A61K31/724A61K31/166A61K31/56
CPCA61K38/085A61K31/166A61K31/56A61K31/724A61P1/08A61P9/02A61P9/06A61P21/02A61K2300/00
Inventor 李华
Owner SUZHOU SCI&TECH TOWN HOSPITAL
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