Dibenzoxepanone compounds and preparation method and use thereof

A technology of dibenzoxepanone and benzoxepanone, applied in the field of dibenzoxepanone compounds, to achieve the effect of highly effective anti-Vibrio parahaemolyticus activity
CN108485987BActive Publication Date: 2020-10-09YANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YANGZHOU UNIV
Publication Date
2020-10-09

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Abstract

The present invention relates to a dibenzoxepanone compound derived from marine fungus WH4-2 and its preparation method and application. The marine fungus Tachybacterium stipe in the present invention has high-efficiency anti-Vibrio parahaemolyticus activity, and The yield of the active substance "dibenzoxepanone compounds containing isopentenyl group" is relatively large, and it is expected to be used in the development of new anti-Vibrio parahaemolyticus drugs. In further activity analysis, it was found that this type of compound also has anti- The activities of Bacillus subtilis, methicillin-resistant Staphylococcus aureus and Enterococcus faecium are expected to be developed into a class of broad-spectrum antibacterial drugs.
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Description

technical field

[0001] The present invention relates to a compound, in particular to a strain of marine fungus and its secondary metabolite "dibenzoxepenyl-containing dibenzoxepanone compound" in anti-parahemolytic Vibrio (V.parahemolyticus) and anti- Applications in the activity of Bacillus subtilis, methicillin-resistant Staphylococcus aureus and Enterococcus faecium. Background technique

[0002] Vibrio parahaemolyticus is a genus of Vibrio in the family Vibrio, with a rod-shaped, filamentous or slightly curved shape. It is a Gram-negative bacterium and is halophilic. It is widely distributed, but it is mainly distributed in seawater and seafood. It is the most common pathogenic bacteria in mariculture. Once an outbreak occurs, the process is fast and difficult to control. Antibiotics are the main means of prevention and treatment at present, but the long-term use of large-scale and large-scale pollution of the marine water environment has also led to the continuous emer...

Claims

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