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A kind of ph-sensitive long-acting repair medical dressing for chronic wound and preparation method thereof

A chronic wound, sensitive technology, applied in the field of intelligent biomedical materials, can solve the problems of low utilization efficiency of antibacterial drugs or active substances, untargeted, untimely treatment of chronic wounds, etc., to enhance the inhibition and resistance of bacterial biofilms. Formation, handling and use are safe and effective in preventing recurrent wound infections

Active Publication Date: 2021-04-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research on chronic wounds, represented by the above-mentioned patents, are all loaded with active substances with different functions to antibacterial or promote wound healing, but they all ignore the complexity and staged healing needs of chronic wounds in the repair process , resulting in low utilization efficiency of antibacterial drugs or active substances, as well as untimely and untargeted treatment of chronic wounds, and the treatment effect is not significant

Method used

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  • A kind of ph-sensitive long-acting repair medical dressing for chronic wound and preparation method thereof
  • A kind of ph-sensitive long-acting repair medical dressing for chronic wound and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] A pH-sensitive long-acting repair medical dressing for chronic wounds, comprising a wound pH-responsive slow-release layer and an immediate-release layer wrapped outside the wound pH-responsive slow-release layer; the immediate-release layer comprises a polymer and antibacterial drugs; the wound pH-responsive slow-release layer contains high molecular polymers, antibacterial drugs and acidity sensitive substances. The preparation method of the pH-sensitive long-acting repair medical dressing for chronic wounds is as follows:

[0036] (1) Preparation of immediate-release layer solution: take 0.5g chitosan (high molecular weight, deacetylation degree is 90%), 0.045g ciprofloxacin hydrochloride mixed and dissolved in 10mL volume ratio with electronic balance scale is 9: 1 In the aqueous acetic acid solution, under the action of magnetic stirrer, stir until completely dissolving to obtain chitosan mass volume fraction and be the quick-release layer solution of 5%;

[0037]...

Embodiment 2

[0041] A pH-sensitive long-acting repair medical dressing for chronic wounds, comprising a wound pH-responsive slow-release layer and an immediate-release layer wrapped outside the wound pH-responsive slow-release layer; the immediate-release layer comprises a polymer and antibacterial drugs; the wound pH-responsive slow-release layer contains high molecular polymers, antibacterial drugs and acidity sensitive substances. The preparation method of the pH-sensitive long-acting repair medical dressing for chronic wounds is as follows:

[0042] (1) Preparation of immediate-release layer solution: take 0.5g chitosan (high molecular weight, deacetylation degree is 90%), 0.045g ciprofloxacin hydrochloride mixed and dissolved in 10mL volume ratio with electronic balance scale is 9: 1 In the aqueous acetic acid solution, under the action of magnetic stirrer, stir until completely dissolving to obtain chitosan mass volume fraction and be the quick-release layer solution of 5%;

[0043]...

Embodiment 3

[0047] A pH-sensitive long-acting repair medical dressing for chronic wounds, comprising a wound pH-responsive slow-release layer and an immediate-release layer wrapped outside the wound pH-responsive slow-release layer; the immediate-release layer comprises a polymer and antibacterial drugs; the wound pH-responsive slow-release layer contains high molecular polymers, antibacterial drugs and acidity sensitive substances. The preparation method of the pH-sensitive long-acting repair medical dressing for chronic wounds is as follows:

[0048] (1) Preparation of immediate-release layer solution: take 0.5g chitosan (high molecular weight, deacetylation degree is 90%), 0.045g ciprofloxacin hydrochloride dissolved in 10mL volume ratio of 9:1 with electronic balance In the aqueous acetic acid solution, stir under the action of a magnetic stirrer until completely dissolving to obtain an immediate-release layer solution whose mass volume fraction of chitosan is 5%;

[0049] (2) Prepar...

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Abstract

The invention provides a pH-sensitive long-acting repair medical dressing for chronic wounds and a preparation method thereof. The pH-sensitive long-term repair medical dressing for chronic wounds is characterized in that it includes a wound pH-responsive slow-release layer and an immediate-release layer wrapped outside the wound pH-responsive slow-release layer; the immediate-release layer Contains polymers and antibacterial drugs; the pH-responsive slow-release layer of the wound contains polymers, antibacterial drugs and acidity sensitive substances. The preparation method of the present invention is simple, the material is easy to obtain, and it is safe to handle and use; the carrier material of the immediate-release layer and the carrier material of the sustained-release layer of the medical film prepared by the present invention have different functions, and can be controlled by fine structure control and acidity-sensitive substances pH response, control the phased release of drugs in the immediate release layer and sustained release layer, meet the needs of different healing stages of wounds, and achieve long-term repair of chronic wounds.

Description

technical field [0001] The invention relates to a pH-sensitive long-acting repair medical dressing for chronic wounds and a preparation method thereof, belonging to the field of intelligent biomedical materials. Background technique [0002] With the continuous development of society and the intensification of population aging, the proportion of chronic wound patients is also increasing. The so-called chronic wounds refer to the wounds that cannot be closed on time according to the procedures and lead to structural defects in the wound site, such as diabetic foot ulcers, pressure sores, vascular ulcers of lower extremities and other difficult-to-heal wounds. Since chronic wounds have a more complex microbial environment, when the wound enters the inflammatory phase, infection is difficult to control. At the same time, in the process of wound healing, due to the lack of active ingredients such as growth factors, the therapeutic effect of chronic wounds is very limited. Theref...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/26A61L15/20A61L15/18A61L15/42A61L15/44A61L15/46
CPCA61L15/18A61L15/20A61L15/26A61L15/28A61L15/325A61L15/42A61L15/44A61L15/46A61L2300/104A61L2300/404A61L2300/406A61L2300/412A61L2300/602C08L5/08C08L67/04C08L75/04C08L79/02
Inventor 高晶郭慧文段红梅张俊王璐
Owner DONGHUA UNIV
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