Pump-free microfluidic chip, preparation method thereof and portable biochemical analysis device

Abstract

The invention discloses a pump-free microfluidic chip, a preparation method thereof and a portable biochemical analysis device. The pump-free microfluidic chip comprises a chip main body and slide glass. The chip main body is provided with a sample injection zone, a pre-reaction zone, a mixing reaction zone, a power zone and a detection zone, and the zones are orderly connected through connectionchannels. A sample injection hole and a detection hole vertically pass through the chip main body. The pre-reaction zone comprises a pre-reaction tank. The mixing reaction zone comprises a meanderingcurved fluid passage. The power zone comprises a diversion channel, a plurality of capillary channels and a flow collection channel. Each one of the capillary channels in the axial direction can extend along the forward and backward directions. The capillary channels are arranged side by side on the plane. The pre-reaction tank, the fluid passage, the diversion channel, the capillary channels, thediversion channel, the first connection channel, the second connection channel, the third connection channel and the forth connection channel are arranged at the bottom of the chip main body and aretightly seal-connected through the slide glass. The pump-free microfluidic chip consumes a small amount of samples, has short detection time and is portable.

Description

technical field [0001] The invention relates to the field of biochemical detection, in particular to a pump-free microfluidic chip, a preparation method thereof, and a portable biochemical analysis device. Background technique [0002] In recent years, microfluidic technology has developed rapidly, and has been extensively researched and applied in various microanalysis systems such as biology, chemistry, and medicine because of its low consumption, rapidity, and multiple analysis functions. Microfluidic chips can integrate chemical or biological laboratories on chips of a few square centimeters to perform sample pretreatment, separation, and detection, and transfer the functions of analytical laboratories to portable devices to the greatest extent. At this stage, the contribution of microfluidic technology in the realization of "on-site real-time detection" is of great significance to the improvement and soundness of global public health. [0003] The rapid development of ...

AI Technical Summary

Problems solved by technology

The disadvantages are: due to the difficulty and high cost of micro-component chip processing, and the relatively poor performance of the micro-valve, problems such as leakage and dead volume may occur, and the actual application effect is not very ideal

The disadvantage is that the chip structure is complex, the driving force is small, and the device preparation is complicated.

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