Novel preparation method of p-fluoronitrobenzene

Abstract

The invention discloses a novel preparation method of p-fluoronitrobenzene, and relates to the field of organic synthesis. The method concretely comprises the following steps of firstly crushing durian shells; adding ethanol; performing ball milling to prepare durian shell powder; then, mixing the durian shell powder with urea; performing sintering treatment at a certain temperature to obtain mixed powder; adding the mixed powder into a tetrabutylammonium chloride solution for stirring and still standing treatment; then, performing drying to obtain a catalyst; adding reaction raw materials ofpara-nitrochloro-benzene, potassium fluoride and the catalyst into a reaction kettle; performing sealing; performing reaction at a certain temperature; after the reaction is completed, performing water washing and layering treatment; performing organic layer rectification to obtain a target product. The method disclosed by the invention has the advantages that the operation is simple; a solvent isnot used in the reaction process; the cost is effectively reduced; the product yield is high.

Description

Technical field: [0001] The invention relates to the field of organic synthesis, in particular to a novel preparation method of p-fluoronitrobenzene. Background technique: [0002] p-Fluoronitrobenzene is an important intermediate for the preparation of medicines, pesticides, dyes, etc. "Ether" is synthesized with it as the main starting material, and its consumption is very large. Therefore, synthetic methods have received widespread attention. [0003] The methods for synthesizing p-fluoronitrobenzene are mainly nitration and fluorination. Compared with nitration, the raw materials of fluorination are simple and easy to obtain, the process operation is convenient, the product selectivity is good, and there is no need to separate isomers, so it is more commonly used. However, at present, many organic solvents are often consumed in the process of preparing p-fluoronitrobenzene by fluorination, which not only increases the preparation cost of p-fluoronitrobenzene, but also ...

AI Technical Summary

Problems solved by technology

However, many organic solvents are often consumed in the process of preparing p-fluoronitrobenzene by the fluorination method, which not only increases the preparation cost of p-fluoronitrobenzene, but also has certain harm to the environment.