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Compound as well as preparation method and application thereof

A technology for compounds and products, applied in the field of medicine, can solve problems such as few species, and achieve the effects of good anti-inflammatory activity and antioxidant activity, high purity, good economic benefits and application prospects

Active Publication Date: 2018-10-12
JIANGHAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In order to solve the problem that there are few types of drugs with anti-inflammatory and antioxidant effects extracted from plants in the prior art, the embodiment of the present invention provides a compound and its preparation method and application

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  • Compound as well as preparation method and application thereof
  • Compound as well as preparation method and application thereof
  • Compound as well as preparation method and application thereof

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Embodiment Construction

[0027] In order to make the purpose, technical solution and advantages of the present invention clearer, the implementation manners of the present invention will be further described in detail below.

[0028] The embodiment of the present invention provides a kind of compound, and the structure of this compound is:

[0029] The name of the compound is (7'R,8S,8'R)-4'-hydroxy-3,3'-dimethoxy-9'-oxo-8-8',9'-O-9- Lignans, wherein, R is R configuration, S is S configuration.

[0030] On the other hand, the embodiment of the present invention also provides a preparation method of the above compound, the preparation method comprising:

[0031] 6 kg of large star anise branches and leaves were soaked overnight with ethanol and then extracted to obtain an extract;

[0032] The extract was concentrated to obtain 650 g of extract;

[0033] Disperse the extract with 2.0L of distilled water, extract with equal volumes of ethyl acetate, recover the ethyl acetate, and obtain the crude p...

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Abstract

The invention discloses a compound as well as a preparation method and application thereof, and belongs to the field of medicine. A name of the compound is (7'R,8S,8'R)-4'-hydroxy-3,3'-dimethoxy-9'-oxo-8-8',9'-O-9-lignans, wherein R is an R configuration and S is an S configuration. The preparation method comprises the following steps: wetting Illicium majus branches and leaves by using ethanol, and performing extraction to obtain an extraction solution; performing concentration on the extraction solution to obtain extract; dispersing the extract by distilled water, performing extraction by using equal-volume ethyl acetate, respectively, recovering the ethyl acetate and obtaining a product of crude extraction; and performing refining on the product of the crude extraction to obtain the compound. The compound disclosed by the invention can better inhibit PAF-stimulated polymorphonuclear leukocyte glucuronidase release and has obvious inhibition activity on Fe<2+> cysteine-induced livermicrosomal lipid peroxidation, and therefore the compound has better anti-inflammatory activity and anti-oxidation effects, and can be used as anti-inflammatory and anti-oxidation drugs.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound and its preparation method and application. Background technique [0002] Searching for drugs with potential clinical application value from traditional Chinese medicine and natural medicine is gradually attracting the attention of researchers. Studies have found that drugs extracted from plants have broad prospects because of their small toxic and side effects. Since there are few types of drugs extracted from plants that have both anti-inflammatory and antioxidant effects, it is urgent to find drugs that have both anti-inflammatory and antioxidant effects extracted from plants to enrich their types. Contents of the invention [0003] In order to solve the problem that there are few types of drugs with anti-inflammatory and anti-oxidative effects extracted from plants in the prior art, the embodiment of the present invention provides a compound and its preparation method an...

Claims

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Application Information

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IPC IPC(8): C07H1/00C07H15/26A61P29/00A61P39/06
CPCA61P29/00A61P39/06C07H1/00C07H15/26
Inventor 方振峰文若剑曹晓琴施璐
Owner JIANGHAN UNIVERSITY
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