Novel royal jelly oral liquid containing 10-HDA liposome, and preparation method thereof

A technology of 10-HDA and royal jelly oral liquid, which is applied in the field of new royal jelly oral liquid containing 10-HDA liposome and its preparation, royal jelly oral liquid and its preparation, and can solve the instability of 10-HDA and affect the health care of royal jelly products And medicinal properties, instability and other issues, to achieve the effect of enhancing health care and medicinal effects, improving stability, and shortening the production cycle

Inactive Publication Date: 2018-10-19
成都巢氏生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has always been believed that 10-HDA has a certain thermal stability, and its content does not change significantly at high temperatures, but research in recent years has found that 10-HDA is actually unstable in royal jelly products, such as 10-HDA in royal jelly frozen Dry powder, royal jelly buccal tablets, royal jelly capsules, royal jelly oral liquid and other products all show obvious instability, especially royal jelly oral liquid, 10-HDA is extremely unstable and drops significantly over time. The decline of 10-HDA content directly affects to the health and medicinal properties of royal jelly products

Method used

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  • Novel royal jelly oral liquid containing 10-HDA liposome, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of a novel royal jelly oral liquid containing 10-HDA liposomes:

[0033] 1) 10-HDA natural extraction:

[0034] Add an equal amount of water to high-quality royal jelly and mix well, store at 0-4°C for 18 hours to crystallize 10-HDA, filter through a 180-mesh filter cloth, and collect royal jelly filtrate and filter residue for later use; filter residue with 95% Extract with ethanol for 2 hours, filter, collect the filtrate, back-extract the filtrate with 3 times of water, mix well and place it at 0-4°C until decenoic acid crystallizes, collect decenoic acid crystals by filtration, and vacuum dry to obtain 10-HDA Pure.

[0035] 2) Preparation of 10-HDA liposomes

[0036] Ultrasonic method: Take 1.1g of 10-HDA and crush it into 40-mesh powder at low temperature, dissolve it in ethanol, add 22g of phospholipid, 6.4g of cholesterol, and 3.1g of dicetyl phosphate, dissolve it in ethanol, and disperse it by ultrasonic to remove most of the ethanol and residual ...

Embodiment 2

[0042] Preparation of a novel royal jelly oral liquid containing 10-HDA liposomes:

[0043] 1) 10-HDA natural extraction:

[0044] Add an equal amount of water to the royal jelly and mix well, store at 0-4°C for 24 hours to crystallize 10-HDA, filter through a 200-mesh filter cloth, and collect the royal jelly filtrate and filter residue separately; use 95% ethanol for the filter residue Extract for 1 hour, filter, collect the filtrate, back-extract the filtrate with 3 times of water, mix it evenly and place it at 0-4°C until the decenoic acid crystallizes, collect the decenoic acid crystals by filtration, and vacuum dry to obtain pure 10-HDA Taste.

[0045] 2) Preparation of 10-HDA liposomes

[0046] High-pressure homogenization method: Take 1.1g of 10-HDA and grind it into 60-mesh powder at low temperature, dissolve it in ethanol, 21.5g of phospholipid, 8.9g of cholesterol, 4.5g of dicetyl phosphate, dissolve it in ethanol, and add the components of the above materials int...

Embodiment 3

[0052] The novel royal jelly oral liquid (II) containing 10-HDA liposome prepared by embodiment 1 and the royal jelly oral liquid (I) stability performance that 10-HDA is not embedded are compared in the following table:

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Abstract

The invention provides a novel royal jelly oral liquid containing 10-HDA liposome, wherein the novel royal jelly oral liquid comprises 10-HDA liposome and a royal jelly hydrolysis liquid, the contentsof the10-HDA liposome are phospholipid, cholesterol, dicetyl phosphate and 10-HDA, and the 10-HDA liposome has good stability in the royal jelly oral liquid. The invention further provides a preparation method, which comprises: preparing 10-HDA liposome, preparing a royal jelly hydrolysis liquid, compounding, packaging, warehousing after passing the test, and carrying out other steps. According to the present invention, the method has characteristics of simple process and short production cycle.

Description

technical field [0001] The invention belongs to the technical field of health food and relates to a royal jelly oral liquid and a preparation method thereof, in particular to a novel royal jelly oral liquid containing 10-HDA liposome and a preparation method thereof. Background technique [0002] Royal jelly is a milky white or light yellow slurry-like substance secreted by the hypopharyngeal glands of young worker bees that cultivate larvae in honeycombs. It is a high-level nutritional food used by worker bees to feed the queen bee and larvae, and it is also a lifelong food for the queen bee. Both at home and abroad, it is regarded as a natural high-grade nutritional product, and many studies have been carried out on it. [0003] 10-HDA is a unique fatty acid in royal jelly that does not contain it. It is a symbolic substance of royal jelly, also known as royal jelly acid. It has the functions of anti-fatigue, anti-radiation, regulating immunity, improving memory, inhibiti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L21/20A23P20/10
CPCA23L21/20A23P20/11
Inventor 陆群敖绍川张全新赖文军
Owner 成都巢氏生物科技有限公司
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