Protein-based liquid band-aid and preparation method thereof

A Band-Aid, protein technology, applied in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve the problems of poor ventilation and anti-infection effect, poor film-forming effect, and high irritation, and achieve fast film-forming speed and speed. , Good breathable and waterproof effect

Inactive Publication Date: 2018-11-06
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some liquid band-aid products currently on the market have poor film-forming effects, strong irritation, easy to fall off, and have disadvantages such as poor ventilation and anti-infection effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 A protein liquid band-aid and its preparation method are as follows: dissolve 10g of keratin in 42g of ethanol solution, keep stirring in a constant temperature water bath at 50°C, add 4g of glycerin, 3.0g of notoginseng powder, and 1.0g of fish Bryanthenin, 60g of ethyl acetate and 80g of isoamyl acetate, the stirring speed is 800rpm, after mixing evenly, the liquid band-aid of the present invention is obtained.

[0017] The mensuration of the liquid band-aid film-forming time of preparation, test method is: choose 10 people of the experimenter of 16~50 years old age group, get the 0.5g band-aid sample of preparation, be applied to the skin surface of volunteer's arm respectively, record every time film-forming time and calculate the average film-forming time.

[0018] The mensuration of the hemostatic and antibacterial effect of the prepared liquid band-aid is as follows: select 10 healthy mice, use a scalpel to scratch the leg muscles of the mice, and immed...

Embodiment 2

[0021] Example 2 A protein liquid band-aid and its preparation method are as follows: dissolve 11g of keratin in 60g of ethanol solution, keep stirring in a constant temperature water bath at 50°C, add 5g of glycerin, 2.9g of notoginseng powder, and 1.1g of fish Hsytysin, 60g of ethyl acetate and 60g of isoamyl acetate were stirred at a speed of 800rpm, and after mixing evenly, the liquid band-aid of the present invention was obtained.

[0022] With the test method of liquid band-aid film-forming time in embodiment 1, the average film-forming time of the liquid band-aid prepared in example 2 is 85s.

[0023] Using the test method of hemostasis and antibacterial effect in Example 1, after treating the mouse wound with the liquid bandage prepared in Example 2, the hemostasis time was 31s, and no infection occurred in any mouse.

Embodiment 3

[0024] Example 3 A protein liquid band-aid and its preparation method are as follows: dissolve 12g of keratin in 56g of ethanol solution, keep stirring in a constant temperature water bath at 50°C, add 6g of glycerin, 2.8g of Panax notoginseng powder, and 1.2g of fish Hssingerin, 62g of ethyl acetate and 60g of isoamyl acetate, the stirring speed is 800rpm, after mixing evenly, the liquid band-aid of the present invention is obtained.

[0025] With the test method of liquid band-aid film-forming time in embodiment 1, the average film-forming time of the liquid band-aid prepared in example 3 is 81s.

[0026] Using the test method of hemostasis and antibacterial effect in Example 1, after treating the mouse wound with the liquid band-aid prepared in Example 3, the hemostasis time was 35s, and no infection occurred in any mouse.

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PUM

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Abstract

The invention discloses a protein-based liquid band-aid and a preparation method thereof. The protein-based liquid band-aid is prepared by mixing keratin, glycerin, notoginseng powder, houttuyin, ethanol, ethyl acetate and isoamyl acetate; the keratin is used as a film former, so that the protein-based liquid band-aid has good biodegradability and biocompatibility, and excellent water resistance and toughness. The protein liquid band-aid has no toxic or side effects or irritation to skin. The protein liquid band-aid is convenient to smear and can be used for protecting various wounds by forming membranes within 1 to 2min after being applied onto the wounds. Moreover, the protein liquid band-aid is soft and elastic, is in good fit with the skin, can be bent freely with the skin, and furtheris not easy to fall off. In addition, the protein-based liquid band-aid has good watertightness and air permeability, can also play roles in hemostasis, pain relief and sterilization, and further caneffectively promote healing of the wounds.

Description

technical field [0001] The invention belongs to the field of medical dressings, and relates to a protein liquid band-aid and a preparation method thereof. Background technique [0002] Wounds will become inflamed and ulcerated after contact with bacteria and water, so it is very important to protect the wound. People usually use Band-Aids to protect wounds. However, the Band-Aids currently on the market have poor air permeability and poor sealing. Water and bacteria can penetrate into the wound through the Band-Aids, which may easily cause wound infection. In addition, for irregular wounds, band-aids are inconvenient to use. Therefore, there is an increasing market demand for band-aids with excellent waterproof and breathable properties. [0003] Liquid band-aids have appeared in the market at present, and liquid band-aids can quickly form a layer of protective film after smearing on the wound, which can achieve the purpose of sterilization and anti-inflammation, such as k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0047A61L26/0066A61L2300/21A61L2300/30A61L2300/404A61L2300/412A61L2300/418A61L2400/04C08L89/00
Inventor 高光辉张钦刘鑫
Owner CHANGCHUN UNIV OF TECH
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