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Compositions comprising nicotinamide riboside and urolithin

A technology of nicotinamide and composition, applied in the field of nutritional and medical formulations of urolithin A and nicotinamide riboside, can solve problems such as not yet predicted

Active Publication Date: 2021-06-18
AMAZENTIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Surprisingly, it has now been found that compositions comprising both nicotinamide riboside and urolithin exhibit a synergistic effect, which had not been predicted

Method used

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  • Compositions comprising nicotinamide riboside and urolithin
  • Compositions comprising nicotinamide riboside and urolithin
  • Compositions comprising nicotinamide riboside and urolithin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] Nicotinamide riboside:

[0021] Nicotinamide riboside is a pyridine mononucleoside form of vitamin B3 that acts as an NAD+ precursor. Its structure is shown in formula (II) below.

[0022]

[0023] Nicotinamide riboside is secreted by yeast and is present as a trace nutrient in some foods. It is available in supplement form (e.g. as its chloride salt, under the trade name NIAGEN TM Available via Chromadex distribution).

[0024] Urolithin:

[0025] Urolithins are metabolites produced by the action of mammalian (including human) gut microbiota on ellagitannins and ellagic acid. Ellagitannins and ellagic acid are compounds commonly found in foods such as pomegranates, nuts and berries. Ellagitannins are minimally absorbed in the gut itself. Urolithins are a class of compounds having the representative structure (I) shown above. The structures of some particularly common urolithins are described in the table below, referenced to structure (I).

[0026]

[002...

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PUM

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Abstract

A composition comprising: a) nicotinamide riboside and b) a urolithin which is a compound of formula (I) or a salt thereof: formula (I) wherein: A, B, C and D are each independently selected from H and OH; W, X, and Y are each independently selected from H and OH; and Z is selected from H and OH. Said composition is suitable for use as a medicament, for example for the treatment of pathological conditions related to muscles, neurodegenerative diseases and / or mitochondrial diseases.

Description

[0001] The present invention relates to nutritional and medical formulations of urolithin and nicotinamide riboside, in particular urolithin A and nicotinamide riboside. The formulation is especially useful for simultaneously enhancing mitophagy and mitochondrial biogenesis to promote optimal mitochondrial function. Background technique [0002] Urolithins have been suggested as treatment agents for a variety of conditions associated with insufficient mitochondrial activity, including obesity, reduced metabolic rate, metabolic syndrome, diabetes, cardiovascular disease, hyperlipidemia, neurodegenerative diseases , cognitive impairment, mood disorders, stress and anxiety conditions; for weight management, or to enhance muscular or mental performance. See WO2012 / 088519 (Amazentis SA). In WO2007 / 127263 (The Regents of the University of California) the use of urolithins for the treatment of various neoplastic diseases is described. [0003] International Patent Publication WO201...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61K31/706A23L29/00
CPCA61K31/366A23L29/00A61K31/706A61P21/00A61P25/28A61K2300/00A23L33/10A23V2002/00A23V2200/316A23V2200/322A61K9/0053
Inventor P.安德鲁克斯C.林施
Owner AMAZENTIS
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