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Composition of traditional Chinese medicine preparation for treating diabetes, its preparation method and application

A composition and diabetes technology, applied in the directions of drug combination, pharmaceutical formula, urinary system diseases, etc., can solve the problems of lack of blood circulation and collaterals, and achieve the effect of lowering blood sugar, improving heart, liver and kidney function, and improving quality.

Active Publication Date: 2022-02-18
TAIJI GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the original formula of Zijiyin lacks the ingredients for promoting blood circulation and dredging collaterals, and treating diarrhea

Method used

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  • Composition of traditional Chinese medicine preparation for treating diabetes, its preparation method and application
  • Composition of traditional Chinese medicine preparation for treating diabetes, its preparation method and application
  • Composition of traditional Chinese medicine preparation for treating diabetes, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 A kind of Chinese medicine composition formula for the treatment of diabetes

[0039] Formula A (by weight): 10 parts of astragalus, 10 parts of rehmannia root, 3 parts of cornus, 6 parts of Chinese yam, 8 parts of curcuma, 3 parts of motherwort, 2 parts of salvia miltiorrhiza, and 2 parts of rhubarb.

[0040] Formula B (by weight): 15 parts of astragalus, 10 parts of rehmannia root, 5 parts of cornus, 8 parts of Chinese yam, 10 parts of curcuma, 5 parts of motherwort, 4 parts of salvia miltiorrhiza, and 4 parts of rhubarb.

[0041] Formula C (by weight): 17 parts of astragalus, 17 parts of rehmannia root, 6 parts of cornus, 9 parts of yam, 11 parts of curcuma, 6 parts of motherwort, 3 parts of salvia miltiorrhiza, and 3 parts of rhubarb.

[0042] Formula D (by weight): 20 parts of astragalus, 20 parts of rehmannia, 8 parts of cornus, 10 parts of Chinese yam, 12 parts of curcuma, 8 parts of motherwort, 5 parts of salvia miltiorrhiza, and 5 parts of rhubarb....

Embodiment 2

[0043] Example 2 Preparation of zedoary oil β-cyclodextrin inclusion compound

[0044] Extraction of zedoary volatile oil: Add 8 times the amount of water to extract zedoary medicinal materials for 6 hours, and collect volatile oil.

[0045] Zedoary volatile oil was clathrated with β-cyclodextrin, using a saturated aqueous solution method, the ratio of oil to β-cyclodextrin was 1:5, the inclusion temperature was 50°C, and the time was 1 hour to obtain zedoary oil β-cyclodextrin. compound.

Embodiment 3

[0046] Embodiment 3 A kind of preparation method of the composition of Chinese medicine preparation for the treatment of diabetes (as attached figure 1 shown)

[0047] 1) Mix the medicinal dregs after extracting volatile oil from Curcuma officinalis with Cornus officinalis and Salvia miltiorrhiza, soak in 70% ethanol for 0.5 hours, heat and reflux twice, add solvent amount to 8 and 6 times, and extract for 2 hours and 1.5 hours respectively;

[0048] 2) Filter the extract extracted in step 1, concentrate the filtrate to a clear paste with a relative density of 1.20 or 1.23 (50°C), add an appropriate amount of water to the clear paste to contain 1g of crude drug per ml, stir evenly, filter, The filtrate was refrigerated for 12 hours, centrifuged (5000r / min), and the supernatant was ultrafiltered (room temperature, 0.05MPa) with an ultrafiltration membrane with a molecular weight cut-off value of 30K to collect 1.25 times the ultrafiltrate of the original volume, and the ultrafi...

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Abstract

The invention belongs to the field of pharmaceutical preparations, and in particular relates to a composition of traditional Chinese medicine preparations for treating diabetes, a preparation method and application thereof. The composition of the traditional Chinese medicine preparation for treating diabetes, the composition is made of the main drug and auxiliary materials, the main drug is composed of the following components by weight: 10-20 parts of astragalus, 10-20 parts of rehmannia glutinosa, cornus officinalis 3-8 parts of meat, 6-10 parts of Chinese yam, 8-12 parts of curcuma, 3-8 parts of motherwort, 2-5 parts of salvia miltiorrhiza, 2-5 parts of rhubarb, the auxiliary materials are β-cyclodextrin and solid preparation auxiliary materials, The β-cyclodextrin is used to include the zedoary volatile oil to form the zedoary oil β-cyclodextrin inclusion complex, and the zedoary volatile oil is obtained by extracting the zedoary; the method for preparing the preparation provided by the present invention improves The quality of the product is improved and the industrialized production is easy; the obtained preparation conforms to the drug standard, has a good hypoglycemic effect, and can improve the heart, liver and kidney functions, abnormal lipid metabolism and retinal microvascular tumor lesions in mice.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a composition of traditional Chinese medicine preparations for treating diabetes, a preparation method and application thereof. Background technique [0002] "Ziji Drink" comes from Zhang Xichun's "Medical Hearts in Chinese and Western Records" in the Qing Dynasty. The prescriptions are raw arrow Qi (five qian), Dashengdi (one liang), raw Huai Yam (one liang), and Jingyu meat (five qian). 1. Raw pig pancreas (chopped, three qian), can nourish the liver, nourish the spleen and strengthen the kidney, and treat diabetes mainly. [0003] Diabetes is a group of clinical syndromes caused by the interaction of genetic and environmental factors, which belongs to the category of "diabetes" disease in traditional Chinese medicine. Diabetic nephropathy (diabetic nephropathy, DN), also known as glomerulosclerosis, is one of the most serious and common microvascular com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K47/69A61P3/10A61P13/12A61P3/00A61P35/00A61P9/00
CPCA61K36/8945A61K36/9066A61K47/6951A61P3/00A61P3/10A61P9/00A61P13/12A61P35/00A61K36/40A61K36/481A61K36/533A61K36/537A61K36/708A61K36/804A61K2236/53A61K2236/51A61K2236/33A61K2236/331
Inventor 董自亮秦少容卿玉玲杨巧巧赵嘉将桑勤禹奇男
Owner TAIJI GROUP
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