Traditional Chinese medicine preparation composition for treatment of diabetes and preparation method and application of traditional Chinese medicine preparation composition

A technology of traditional Chinese medicine preparations and diabetes, which can be used in drug combinations, medical formulas, urinary system diseases, etc., and can solve problems such as lack of blood circulation and collaterals

Active Publication Date: 2018-12-25
TAIJI GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the original formula of Zijiyin lacks the ingredients for promoting blood circulation and dredging collaterals, and treating diarrhea

Method used

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  • Traditional Chinese medicine preparation composition for treatment of diabetes and preparation method and application of traditional Chinese medicine preparation composition
  • Traditional Chinese medicine preparation composition for treatment of diabetes and preparation method and application of traditional Chinese medicine preparation composition
  • Traditional Chinese medicine preparation composition for treatment of diabetes and preparation method and application of traditional Chinese medicine preparation composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 A kind of Chinese medicine composition formula for the treatment of diabetes

[0040] Formula A (by weight): 10 parts of astragalus, 10 parts of rehmannia root, 3 parts of cornus, 6 parts of Chinese yam, 8 parts of curcuma, 3 parts of motherwort, 2 parts of salvia miltiorrhiza, and 2 parts of rhubarb.

[0041] Formula B (by weight): 15 parts of astragalus, 10 parts of rehmannia root, 5 parts of cornus, 8 parts of yam, 10 parts of curcuma, 5 parts of motherwort, 4 parts of salvia miltiorrhiza, and 4 parts of rhubarb.

[0042] Formula C (by weight): 17 parts of astragalus, 17 parts of rehmannia root, 6 parts of cornus, 9 parts of yam, 11 parts of curcuma, 6 parts of motherwort, 3 parts of salvia miltiorrhiza, and 3 parts of rhubarb.

[0043] Formula D (by weight): 20 parts of astragalus, 20 parts of rehmannia root, 8 parts of cornus, 10 parts of yam, 12 parts of curcuma, 8 parts of motherwort, 5 parts of salvia miltiorrhiza, and 5 parts of rhubarb.

Embodiment 2

[0044] Example 2 Preparation of zedoary oil β-cyclodextrin inclusion compound

[0045] Extraction of zedoary volatile oil: Add 8 times the amount of water to extract zedoary medicinal materials for 6 hours, and collect volatile oil.

[0046] Zedoary volatile oil was clathrated with β-cyclodextrin, using a saturated aqueous solution method, the ratio of oil to β-cyclodextrin was 1:5, the inclusion temperature was 50°C, and the time was 1 hour to obtain zedoary oil β-cyclodextrin. compound.

Embodiment 3

[0047] Embodiment 3 A kind of preparation method of the composition of Chinese medicine preparation for the treatment of diabetes (as attached figure 1 shown)

[0048] 1) Mix the dregs of curcuma after extracting volatile oil with Cornus officinalis and Salvia miltiorrhiza, soak in 70% ethanol for 0.5 hour, heat and reflux twice, add solvent amount to 8, 6 times, and extract for 2 hours and 1.5 hours respectively;

[0049] 2) Filter the extract obtained in step 1, concentrate the filtrate to a clear paste with a relative density of 1.20 or 1.23 (50°C), add an appropriate amount of water to the clear paste to contain 1 g of crude drug per ml, stir evenly, and filter. The filtrate was refrigerated for 12 hours, centrifuged (5000r / min), and the supernatant was ultrafiltered (room temperature, 0.05MPa) with an ultrafiltration membrane with a molecular weight cut-off value of 30K to collect 1.25 times the ultrafiltrate of the original volume, and the ultrafiltrate was concentrated...

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Abstract

The invention belongs to the field of medicinal preparations and particularly relates to a traditional Chinese medicine preparation composition for treatment of diabetes and a preparation method and application of the traditional Chinese medicine preparation composition. The composition is composed of a main drug and an auxiliary material, wherein the main drug comprises, by weight, 10-20 parts ofastragalus membranaceus, 10-20 parts of radix rehmanniae, 3-8 parts of pulp of dogwood fruit, 6-10 parts of yam, 8-12 parts of curcuma zedoary, 3-8 parts of leonurus, 2-5 parts of the root of red-rooted salvia and 2-5 parts of rheum officinale; the auxiliary material comprises beta-cyclodextrin and a solid preparation, the beta-cyclodextrin is used for including curcuma zedoaria volatile oil to form zedoary turmeric oil beta-cyclodextrin inclusion compound, and the curcuma zedoaria volatile oil is extracted with curcuma zedoary. With the mehod, quality of the product is improved, and industrialized production is facilitated; the obtained preparation meets the standards for drug use, good hypoglycemic effect is achieved, and heart liver and kidney functions, abnormal lipids metabolism andretinal microangioma lesion of small mice can be improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a composition of traditional Chinese medicine preparations for treating diabetes, a preparation method and application thereof. Background technique [0002] "Ziji Drink" comes from Zhang Xichun's "Medical Hearts in Chinese and Western Records" in the Qing Dynasty. The prescriptions are raw arrow Qi (five qian), Dashengdi (one liang), raw Huai Yam (one liang), and Jingyu meat (five qian). 1. Raw pig pancreas (chopped, three qian), can nourish the liver, nourish the spleen and strengthen the kidney, and treat diabetes mainly. [0003] Diabetes is a group of clinical syndromes caused by the interaction of genetic and environmental factors, which belongs to the category of "diabetes" disease in traditional Chinese medicine. Diabetic nephropathy (diabetic nephropathy, DN), also known as glomerulosclerosis, is one of the most serious and common microvascular com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K47/69A61P3/10A61P13/12A61P3/00A61P35/00A61P9/00
CPCA61K36/8945A61K36/9066A61K47/6951A61P3/00A61P3/10A61P9/00A61P13/12A61P35/00A61K36/40A61K36/481A61K36/533A61K36/537A61K36/708A61K36/804A61K2236/53A61K2236/51A61K2236/33A61K2236/331A61K2300/00
Inventor 董自亮秦少容卿玉玲杨巧巧赵嘉将桑勤禹奇男
Owner TAIJI GROUP
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