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Application of human urinary kininogenase in preparation of medicine for treating hypertension complicated with hyperlipidemia

A technology of urinary kininogenase and hyperlipidemia, which is applied in the field of medicine, can solve the problems of large toxic side effects, few drugs, and high prices, and achieve a significant synergistic effect

Active Publication Date: 2019-10-08
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing drugs for the treatment of hypertension and hyperlipidemia are mainly chemical drugs, and they are relatively single. They either treat high blood pressure or treat hyperlipidemia. There are fewer drugs for the combination of the two, and the price is expensive. Long-term use has relatively serious side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, an injection for the treatment of hypertension combined with hyperlipidemia

[0023] Take filter-sterilized human urinary kininogenase 100PNA units, add an appropriate amount of water for injection to dissolve, then add breviscapine 25mg, dissolve, adjust the pH to neutral, add water for injection to 1000mL, add sodium chloride to adjust isotonicity, Sterile filtration, packing into 1000 ampoules.

Embodiment 2

[0024] Embodiment 2, an injection for the treatment of hypertension combined with hyperlipidemia

[0025] Take filter-sterilized human urinary kininogenase 150PNA units, add appropriate amount of water for injection to dissolve, then add breviscapine 40mg, dissolve, adjust pH to neutral, add water for injection to 1000mL, add sodium chloride to adjust isotonicity, Sterile filtration, packing into 1000 ampoules.

Embodiment 3

[0026] Embodiment 3, an injection for the treatment of hypertension combined with hyperlipidemia

[0027] Take filter-sterilized human urinary kininogenase 200PNA units, add an appropriate amount of water for injection to dissolve, then add breviscapine 45mg, dissolve, adjust the pH to neutral, add water for injection to 1000mL, add sodium chloride to adjust isotonicity, Sterile filtration, packing into 1000 ampoules.

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PUM

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Abstract

The invention belongs to the field of medicine, in particular to a novel medical use of human urinary kininogenase, namely the application of human urinary kallikrein in the preparation of medicine for treating hypertension complicated with hyperlipidemia. Additionally, the present invention provides pharmaceutical compositions comprising human urinary kininogenase, comprising human urinary kininogenase and breviscapine, the main dosage form of which is an injection, usually administered intravenously. In the invention, the human urinary kininogenase composition has remarkable therapeutic effect on hypertension complicated with hyperlipidemia.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to a new medical application of human urinary kininogenase, that is, the application of human urinary kininogenase in the preparation of medicines for treating hypertension combined with hyperlipidemia. Background technique: [0002] Human urinary kininogenase is a refined glycoprotein extracted from healthy male urine, with a molecular weight of about 54,000 Daltons. It can activate the conversion of human plasma kininogen into kinin, dilate blood vessels, increase blood flow, and improve blood circulation. , and also increase the deformability of red blood cells and inhibit platelet aggregation, prolong recalcification time and improve blood viscosity. In recent years, with the in-depth research on human urokininogenase, more and more new uses of human urokininogenase have been found. For example, Chinese patent CN101134106B discloses a pharmaceutical composition containing hum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/48A61P9/12A61P3/06A61K31/7048
Inventor 张志军严铭娟宋建东徐虹
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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