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Use of ulinastatin-containing pharmaceutical composition in preparation of medicine for treating gallbladder cancer

A technology for ulinastatin and a composition is applied in the field of preparing medicines for treating gallbladder cancer, which can solve the problem that no gallbladder cancer has been found, and achieve the effects of significant curative effect and low toxic and side effects

Active Publication Date: 2019-10-08
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, there is no relevant research on the pharmaceutical composition of ulinastatin and β-escin sodium in the treatment of gallbladder cancer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Ulinastatin 30.0mg β-Aescin Sodium 6.0mg

[0017] Preparation process: Take prescription amount of ulinastatin and β-escin sodium, dissolve in 500ml 0.9% physiological saline injection, filter, pot, and sterilize at 100°C for 30 minutes to obtain the product.

Embodiment 2

[0019] Ulinastatin 30.0mg β-Aescin Sodium 15.0mg

[0020] Preparation process: Take prescription amount of ulinastatin and β-escin sodium, dissolve in 500ml 0.9% physiological saline injection, filter, pot, and sterilize at 100°C for 30 minutes to obtain the product.

Embodiment 3

[0022] Ulinastatin 30.0mg β-Aescin Sodium 12.0mg

[0023] Preparation process: Take the prescribed amount of ulinastatin and β-escin sodium, add 20 grams of mannitol to dissolve, adjust the pH to neutral, add water for injection to 2000 ml, add sodium chloride to adjust isotonicity, and filter aseptically , packed in 1000 vials, and freeze-dried under aseptic conditions.

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PUM

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Abstract

The invention belongs to the field of medical technology and particularly discloses application of an ulinastatin-containing pharmaceutical composition to preparation of a medicine for treating carcinoma of the gall-bladder. The pharmaceutical composition comprises ulinastatin and beta-aescin natrum. Animal tests verify that the pharmaceutical composition can play an obvious inhibition function on human gall-bladder carcinoma nude-mouse transplanted tumor, is low in toxic and side effect and high in security and can serve as the medicine for treating carcinoma of the gall-bladder.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically discloses the use of a pharmaceutical composition containing ulinastatin in the preparation of medicines for treating gallbladder cancer. Background technique [0002] Gallbladder cancer (carcinoma of the gall-blader) occupies the first place among gallbladder malignant tumors, and other types include sarcoma, carcinoid, primary malignant melanoma, and giant cell adenocarcinoma. Primary gallbladder carcinoma is relatively rare clinically, and has not attracted people's attention for a long time. According to domestic textbook reports, it only accounts for about 1% of all cancers. Due to the extensive development of imaging examinations such as B-ultrasound and CT, gallbladder cancer has been gradually recognized and the detection rate has increased. However, the incidence of gallbladder cancer has obvious regional differences, and the incidence of gallbladder cancer patients is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/57A61K9/19A61K9/08A61P35/00A61K31/704
Inventor 孙明晖李翰明赵菁宋建东
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD