Use of human urinary kininogenase in preparation of medicine for treating migraine and its composition
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of kininogenase and composition, which is applied in the field of medicine, can solve problems such as adverse reactions, and achieve the effects of reducing the incidence of adverse reactions, good stability, and improving compliance
Active Publication Date: 2020-05-05
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
View PDF8 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
At present, there is no relevant report on the combined application of human urinary kininogenase and Panax notoginseng saponins for the treatment of migraine. There is a great need for a new and effective pharmaceutical composition for the treatment of migraine
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0019] Embodiment 1, human urinary kallikrein injection of the present invention
[0020] Take filter-sterilized human urinary kininogenase 150PNA units, add an appropriate amount of water for injection to dissolve, adjust the pH value to neutral, add water for injection to 1000mL, add sodium chloride to adjust isotonicity, filter aseptically, and pack 1000 pieces In ampoules, you can.
Embodiment 2
[0021] Embodiment 2, the present invention treats the injection of migraine
[0022] Take filter-sterilized human urinary kininogenase 72PNA unit, add an appropriate amount of water for injection to dissolve, then add 3g of Panax notoginseng saponins, dissolve, adjust the pH to neutral, add water for injection to 1000mL, add sodium chloride to adjust isotonicity , sterile filtered, and packed in 1000 ampoules.
Embodiment 3
[0023] Embodiment 3, the present invention treats the injection of migraine
[0024] Take filter-sterilized human urinary kininogenase 150PNA units, add an appropriate amount of water for injection to dissolve, then add 4.5g of Panax notoginseng saponins, dissolve, adjust the pH to neutral, add water for injection to 1000mL, add sodium chloride to adjust, etc. Infiltration, sterile filtration, and packing into 1000 ampoules.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
molecular weight
aaaaa
aaaaa
Login to view more
Abstract
The invention belongs to the technical field of medicines and in particular relates to application of human urinary kallidinogenase in preparing a medicine for treating migraine, and a medicine composition for treating migraine. The invention provides application of human urinary kallidinogenase in treating migraine. The invention further provides a medicine composition for treating migraine. Themedicine composition comprises human urinary kallidinogenase and panax notoginseng saponins. The medicine composition has a synergetic function in treating migraine, and has the advantages of being remarkable in treatment effect, simple in preparation process, low in adverse reaction rate, and the like.
Description
technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the use of human urinary kininogenase in preparing medicine for treating migraine and its composition. Background technique [0002] Human urinary kallikrein is a refined glycoprotein extracted from the urine of healthy men, with a molecular weight of about 54,000 Da, which is a single chain composed of 238 amino acids. Human urinary kininogenase can activate human plasma kininogen into kinin, dilate capillaries, antithrombotic, improve blood circulation, increase blood flow, anticoagulant, thrombolysis, reduce blood viscosity, increase red blood cell deformability and inhibit Platelet aggregation, etc., is a class of proteases with high application value. [0003] Headache is one of the most common clinical symptoms, especially migraine among primary headaches. With the development of social economy and the increase of life pressure, the prevalence of migraine has ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more