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Application and composition of human urinary kallidinogenase in preparing medicine for treating migraine

A technique for urinary kallikrein and kallikrein, which is applied in the field of medicine, can solve problems such as adverse reactions, and achieve the effects of reducing the incidence of adverse reactions, improving stability and improving compliance.

Active Publication Date: 2018-12-28
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the combined application of human urinary kininogenase and Panax notoginseng saponins for the treatment of migraine. There is a great need for a new and effective pharmaceutical composition for the treatment of migraine

Method used

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  • Application and composition of human urinary kallidinogenase in preparing medicine for treating migraine
  • Application and composition of human urinary kallidinogenase in preparing medicine for treating migraine
  • Application and composition of human urinary kallidinogenase in preparing medicine for treating migraine

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Embodiment 1, human urinary kallikrein injection of the present invention

[0020] Take filter-sterilized human urinary kininogenase 150PNA units, add an appropriate amount of water for injection to dissolve, adjust the pH value to neutral, add water for injection to 1000mL, add sodium chloride to adjust isotonicity, filter aseptically, and pack 1000 pieces In ampoules, you can.

Embodiment 2

[0021] Embodiment 2, the present invention treats the injection of migraine

[0022] Take filter-sterilized human urinary kininogenase 72PNA unit, add an appropriate amount of water for injection to dissolve, then add 3g of Panax notoginseng saponins, dissolve, adjust the pH to neutral, add water for injection to 1000mL, add sodium chloride to adjust isotonicity , sterile filtered, and packed in 1000 ampoules.

Embodiment 3

[0023] Embodiment 3, the present invention treats the injection of migraine

[0024] Take filter-sterilized human urinary kininogenase 150PNA units, add an appropriate amount of water for injection to dissolve, then add 4.5g of Panax notoginseng saponins, dissolve, adjust the pH to neutral, add water for injection to 1000mL, add sodium chloride to adjust, etc. Infiltration, sterile filtration, and packing into 1000 ampoules.

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Abstract

The invention belongs to the technical field of medicines and in particular relates to application of human urinary kallidinogenase in preparing a medicine for treating migraine, and a medicine composition for treating migraine. The invention provides application of human urinary kallidinogenase in treating migraine. The invention further provides a medicine composition for treating migraine. Themedicine composition comprises human urinary kallidinogenase and panax notoginseng saponins. The medicine composition has a synergetic function in treating migraine, and has the advantages of being remarkable in treatment effect, simple in preparation process, low in adverse reaction rate, and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the use of human urinary kininogenase in preparing medicine for treating migraine and its composition. Background technique [0002] Human urinary kallikrein is a refined glycoprotein extracted from the urine of healthy men, with a molecular weight of about 54,000 Da, which is a single chain composed of 238 amino acids. Human urinary kininogenase can activate human plasma kininogen into kinin, dilate capillaries, antithrombotic, improve blood circulation, increase blood flow, anticoagulant, thrombolysis, reduce blood viscosity, increase red blood cell deformability and inhibit Platelet aggregation, etc., is a class of proteases with high application value. [0003] Headache is one of the most common clinical symptoms, especially migraine among primary headaches. With the development of social economy and the increase of life pressure, the prevalence of migraine has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K9/00A61P25/06A61K36/258
CPCA61K9/0019A61K36/258A61K38/482A61P25/06C12Y304/21106A61K2300/00
Inventor 张志军严铭娟宋建东徐虹
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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