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Catheter with sleeve film capable of protecting tissue and preparation method and application thereof

A mantle, protective technology, used in ophthalmic surgery, medical science, surgery, etc., to prevent tissue adhesion, prevent tear damage, and prevent adhesion.

Active Publication Date: 2019-02-01
GUANGZHOU YUEQING REGENERATION MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcomings and deficiencies of the existing artificial lacrimal ducts, the primary purpose of the present invention is to provide a catheter with a tissue-protective mantle. The membrane is double-layered, which are the outer anti-adhesion layer and the inner lubricating layer, both of which are composed of biomedical polymers. When implanted, it can not only prevent adhesion, but also the mantle can be easily separated from the tube core to avoid contact with the tissue. protection against adhesion damage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The silicone rubber catheter with a diameter of 0.6mm is fully dried as the main tube core, preheated with hot air and immersed in PEG (molecular weight 2k) 80 o The C melt was slowly taken out after 5s, cooled naturally, and the thickness of the obtained inner layer was 0.2mm, then it was fully immersed in 0.1% chitosan (150k) acetic acid solution for 1s, and then vertically taken out to dry, and the outer layer with a thickness of 0.01mm was obtained , the material is shaped by 0.01M sodium hydroxide solution, rinsed twice in pure water, and dried to obtain the product.

Embodiment 2

[0040] After the TPU catheter with a diameter of 0.6mm is fully dried, it is used as the main tube core, immersed in 10% PVP (molecular weight 40k) alcohol solution for 10s, then cooled naturally, repeated twice, and the thickness of the inner layer obtained is 0.22mm, and then fully immersed Put it in 3% sodium alginate (80k) solution for 5 seconds and then quickly dry it to obtain an outer layer with a thickness of 0.15mm. The material is shaped by 0.05M calcium chloride solution, rinsed twice in pure water, and dried to obtain the product .

Embodiment 3

[0042] A TPE catheter with a diameter of 0.8mm is fully dried as the main tube core, immersed in a 0.5% PEG (molecular weight 20k) methylene chloride solution for 2 seconds, then taken out, vacuum-dried to obtain an inner layer with a thickness of 0.1mm, and then fully immersed in 0.5% Put it in the hyaluronic acid (1000k) solution for 1 second and then lift it up vertically to dry to obtain an outer layer with a thickness of 0.08mm. The material is subjected to a 0.05M BDDE solution for 5 minutes, washed and dried, repeated twice, and rinsed twice in pure water. , to obtain the product after drying.

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Abstract

The invention discloses a catheter with sleeve film capable of protecting tissue, a preparation method and application thereof. The material is composed of a catheter core and the sleeve film wrappedaround the outer portion of the catheter, wherein the sleeve film comprises an outer layer anti-adhesion layer and an inner layer lubricating layer, and the outer layer anti-adhesion layer and the inner layer lubricating layer are both made from a biomedical material. The catheter with the sleeve film capable of protecting the tissue and the preparation method and application thereof have the advantages that the outer layer anti-adhesion layer of the sleeve film is made from the water-soluble biomedical material, the outer layer can play an anti-adhesion role when the catheter is implanted into the body, and the inner layer material can exert a plasticizer function and a lubrication function after being dissolved by a tissue fluid, so that the tear damage caused by adhesion when tube taking can be reduced, the catheter is suitable for being used as a component material of the lacrimal duct intubation, and the anti-adhesion performance of an existing materials is improved.

Description

technical field [0001] The invention relates to the field of biomedical devices, in particular to a catheter with a tissue-protective mantle, a preparation method and application thereof, which can be implanted as a medical device component for drainage for lacrimal duct reconstruction surgery. Background technique [0002] Chronic dacryocystitis, canaliculus stenosis, nasolacrimal duct stenosis, puncta stenosis, obstruction, and canaliculus rupture are common and frequently-occurring diseases in ophthalmology, accounting for about 3% of the cases treated in ophthalmology. The reason is inflammation , trauma, tumor, congenital anomaly, and parasites, etc., the clinical symptoms are epiphora or profuse tearing, and pus. In acute attacks, the skin at the lower part of the inner corner of the eye is red, swollen, and painful. In severe cases, it can lead to blindness and even invade the intracranial It is life-threatening and has a great impact on the life and work of patients....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/007A61L31/04A61L31/06
CPCA61F9/00772A61L31/042A61L31/048A61L31/06C08L71/02C08L39/06C08L5/08C08L5/04
Inventor 别拓铭易静楠张爱华官习鹏
Owner GUANGZHOU YUEQING REGENERATION MEDICINE TECH CO LTD
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