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Vitamin C injection and preparation method thereof

A technology for vitamins and injections, which is applied in medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as easy oxidation, yellowing and deterioration of medicinal liquids, etc.

Inactive Publication Date: 2019-03-08
江西润泽药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned prior art, the purpose of the present invention is to overcome the problems that the general vitamin C injection in the prior art is easy to oxidize, causing the yellowing and deterioration of the medicinal solution, thereby providing a method that can effectively reduce the oxidation degree of the vitamin C injection and improve the quality of the vitamin C injection. Its quality and storage time, vitamin C injection and preparation method thereof to avoid problems such as yellowing of medicinal liquid

Method used

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preparation example Construction

[0017] The invention provides a method for preparing vitamin C injection, wherein the preparation method comprises:

[0018] 1) Pass CO into water for injection 2 to CO 2 The concentration is 1.2-1.449g / L, makes solvent;

[0019] 2) adding disodium ethylenediamine tetraacetate and vitamin C to the solvent prepared in step 1) and mixing to obtain the first solution;

[0020] 3) adding sodium bicarbonate and sodium bisulfite to the first solution, and adjusting the pH to 5.9-6.2 to prepare the second solution;

[0021] 4) Decarburization after adding activated carbon to the second solution and mixing to obtain the third solution;

[0022] 5) The third solution is subjected to coarse filtration and fine filtration in sequence to obtain vitamin C injection; wherein,

[0023] The pore size of the filter membrane in the rough filtration process is 0.4-0.6 μm, and the pore size of the filter membrane in the fine filtration process is 0.1-0.3 μm.

[0024] The present invention pa...

Embodiment 1

[0035] 1) Pass CO into 100 parts by weight of water for injection 2 to CO 2 The concentration is 1.2g / L, makes solvent;

[0036] 2) Add 0.03 parts by weight of disodium ethylenediaminetetraacetic acid to the solvent prepared in step 1) to dissolve, then add 3 parts by weight of vitamin C therein and mix to obtain the first solution;

[0037] 3) Add 2 parts by weight of sodium bicarbonate and 0.1 part by weight of sodium bisulfite to the first solution, and adjust the pH to 6 to prepare the second solution;

[0038] 4) Add activated carbon to the second solution, stir and mix for 15 minutes at a stirring rate of 100 r / min at 50°C, and then decarburize by suction filtration to obtain the third solution;

[0039] 5) The third solution was subjected to coarse filtration with a pore size of 0.45 μm and fine filtration with a pore size of 0.22 μm in sequence, and then steam sterilized at 100° C. for 20 minutes to prepare vitamin C injection A1.

Embodiment 2

[0041] 1) Pass CO into 100 parts by weight of water for injection 2 to CO 2 The concentration of is 1.449g / L, makes solvent;

[0042] 2) Add 0.08 parts by weight of disodium edetate to the solvent prepared in step 1) to dissolve, and then add 8 parts by weight of vitamin C therein and mix to obtain the first solution;

[0043] 3) Add 5 parts by weight of sodium bicarbonate and 0.3 parts by weight of sodium bisulfite to the first solution, and adjust the pH to 6 to prepare the second solution;

[0044] 4) Add activated carbon to the second solution, stir and mix for 20 minutes at 60°C at a stirring rate of 300r / min, and then decarburize by suction filtration to obtain the third solution;

[0045] 5) The third solution was subjected to coarse filtration with a pore size of 0.45 μm and fine filtration with a pore size of 0.22 μm in sequence, and then steam sterilized at 100° C. for 20 minutes to prepare vitamin C injection A2.

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Abstract

The invention discloses vitamin C injection and a preparation method thereof. The preparation method comprises the following steps: 1) introducing CO2 into water for injection until the concentrationof the CO2 is 1.2 to 1.449 g / L, so as to prepare a solvent; 2) adding disodium ethylenediaminetetraacetate and vitamin C into the solvent prepared in step 1) and mixing to prepare a first solution; 3)adding sodium bicarbonate and sodium hydrogen sulfite into the first solution; regulating the pH (Potential of Hydrogen) to be 5.9 to 6.2 to prepare a second solution; 4) adding activated carbon intothe second solution and mixing; then decarbonizing to prepare a third solution; 5) carrying out rough filtering and fine filtering on the third solution in sequence to prepare the vitamin C injection, wherein the pore diameter of a filter membrane in the rough filtering process is 0.4 to 0.6 mum and the pore diameter of a filter membrane in the fine filtering process is 0.1 to 0.3 mum. By adopting the preparation method provided by the invention, the oxidization degree of the vitamin C injection can be effectively lowered and the quality and preservation time of the vitamin C injection are improved; the problems that medicine liquid becomes yellow and the like are avoided.

Description

technical field [0001] The invention relates to the field of production and preparation of vitamin C injection, in particular to vitamin C injection and a preparation method thereof. Background technique [0002] Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. Its aqueous solution is acidic and easily oxidized in the air, resulting in its injection being easily oxidized, decomposed and discolored, resulting in yellowing of the liquid medicine, unstable pH value, and content Decrease and other problems, resulting in difficult storage of liquid medicine, uncontrollable quality, etc. [0003] Therefore, it is an urgent problem to be solved in the present invention to provide a vitamin C injection that can effectively reduce the degree of oxidation of the vitamin C injection, improve its quality and storage time, and avoid problems such as yellowing of the liquid medicine and its preparation method. Contents of the invention [0004] In view of the above-m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/02A61K47/04A61K47/18A61K31/375
CPCA61K9/0019A61K9/08A61K31/375A61K47/02A61K47/183
Inventor 邹明明胡贤德徐满
Owner 江西润泽药业有限公司
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