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Tooth desensitizing gel and preparation method thereof

A technology for sensitizing gel and teeth, which is applied in the field of tooth desensitization gel and its preparation, can solve problems such as unsatisfactory effects, and achieve effects of no toxic side effects, quick results, and simple production

Inactive Publication Date: 2019-03-12
济南秦鲁药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The effect of current drugs for treating dentin hypersensitivity is generally unsatisfactory. For this reason, there is an urgent need to find new materials to achieve long-term and efficient treatment of dentin hypersensitivity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The tooth desensitizing gel of the present invention comprises the raw materials of following weight: 3 kilograms of carbomer 980, 0.05 kilogram of sodium paraben complex ester, 1 kilogram of sodium hydroxide, 0.5 kilogram of polyethylene glycol 8000, EDTA -2NA is 0.05 kg, potassium nitrate is 2 kg, sodium fluoride is 0.1 kg, and purified water is 85 kg. Lemon essence 1 kg.

[0021] A preparation method of tooth desensitization gel, comprising the following steps:

[0022] (1) Dissolve sodium paraben complex ester and sodium hydroxide with 60 kg of water, then add Carbomer 980 and stir to dissolve, dissolve for 5 hours, and stir evenly every 1 hour;

[0023] (2) Use the remaining water to dissolve polyethylene glycol 8000, EDTA-2Na, potassium nitrate, and sodium fluoride, and stir until completely dissolved to obtain a mixed solution;

[0024] (3) Stir the mixed solution in step (2) into the liquid in step (1) and stir until uniform, then add essence and stir well;

...

Embodiment 2

[0028] The tooth desensitization gel of the present invention comprises the raw materials of following weight: carbomer 980 is 5 kilograms, sodium paraben complex ester is 1 kilogram, sodium hydroxide is 3 kilograms, polyethylene glycol 8000 is 3 kilograms, EDTA 1 kg of -2NA, 4 kg of potassium nitrate, 1 kg of sodium fluoride, and 95 kg of purified water. 2 kg of lemon essence.

[0029] A preparation method of tooth desensitization gel, comprising the following steps:

[0030] (1) Dissolve sodium paraben complex ester and sodium hydroxide with 60 kg of water, then add Carbomer 980 and stir to dissolve, dissolve for 12 hours, and stir evenly every 1 hour;

[0031] (2) Use the remaining water to dissolve polyethylene glycol 8000, EDTA-2Na, potassium nitrate, and sodium fluoride, and stir until completely dissolved to obtain a mixed solution;

[0032] (3) Stir the mixed solution in step (2) into the liquid in step (1) and stir until uniform, then add essence and stir well;

[...

Embodiment 3

[0036] The tooth desensitizing gel of the present invention comprises the raw materials of following weight: carbomer 980 is 4 kg, sodium paraben complex ester is 0.1 kg, sodium hydroxide is 1.4 kg, polyethylene glycol 8000 is 1 kg, EDTA -2NA is 0.1 kg, potassium nitrate is 3 kg, sodium fluoride is 0.4 kg, and purified water is 90 kg.

[0037] A preparation method of tooth desensitization gel, comprising the following steps:

[0038] (1) Dissolve sodium paraben complex ester and sodium hydroxide with 60 kg of water, then add Carbomer 980 and stir to dissolve, dissolve for 8 hours, and stir evenly every 1 hour;

[0039] (2) Use the remaining water to dissolve polyethylene glycol 8000, EDTA-2Na, potassium nitrate, and sodium fluoride, and stir until completely dissolved to obtain a mixed solution;

[0040] (3) Add the mixed solution in step (2) into the liquid in step (1) while stirring until uniform;

[0041] (4) Static defoaming for 4 hours;

[0042] (5), filling.

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PUM

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Abstract

Disclosed is a preparation method of a tooth desensitizing gel. The preparation method of the tooth desensitizing gel is characterized by comprising the following steps of (1) dissolving nipagin compound sodium acetate and sodium hydroxide in 60 parts of water by weight part, mixing in carbomer 980 for dissolution for 5-12 hours, and uniformly stirring the mixture every one hour; (2) completely dissolving polyethylene glycol 8000, EDTA-2Na (ethylenediaminetetraacetic acid disodium salt), potassium nitrate and sodium fluoride to obtain a mixed solution; (3) uniformly stirring the mixed solutionfrom the step (2) into the solution from the step (1); (4) standing the mixture for 3-5 hours to remove bubbles; (5) performing a filling process. The prepared tooth desensitizing gel has the advantages of being simple in preparation, convenient to use, good in therapeutic effects, quick in effect, free from toxic and side effects, safe, reliable and mainly applicable to symptoms such as hemodia,dentine hypersensitivity and toothache caused by nervous disorder.

Description

technical field [0001] The invention relates to the technical field of medical preparations, in particular to a tooth desensitizing gel and a preparation method thereof. Background technique [0002] Dentin hypersensitivity, also known as dentin hypersensitivity and hypersensitive dentin, is the soreness caused by external stimuli such as temperature (cold, heat), chemical substances (sour, sweet) and mechanical action (friction, biting hard objects), etc. symptom. It is caused by the damage of the integrity of the enamel and the exposure of the dentinal tubules to the oral environment, which causes irritation. Dentin hypersensitivity can occur in abrasion, wedge-shaped defect, tooth fracture, caries, and periodontal atrophy. [0003] The effect of current drugs for treating dentin hypersensitivity is generally unsatisfactory. Therefore, it is urgent to find new materials to achieve long-term and efficient treatment of dentin hypersensitivity. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/16A61K9/06A61P1/02A61P37/08
CPCA61K9/0063A61K9/06A61K33/16A61K47/32A61P1/02A61P37/08
Inventor 朱坤福王素丹孟茹朱琳
Owner 济南秦鲁药业科技有限公司
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