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Application of mt-2a gene snp site in detection of susceptibility to heavy metal poisoning

A MT-2A, heavy metal technology, applied in the field of biomedical molecular detection, can solve problems such as less research, achieve the effects of reducing manual operations, controlling detection costs, and saving time

Active Publication Date: 2022-05-10
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are few studies on the relationship between MT-2A gene polymorphism and susceptibility to heavy metal (such as cadmium) poisoning

Method used

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  • Application of mt-2a gene snp site in detection of susceptibility to heavy metal poisoning
  • Application of mt-2a gene snp site in detection of susceptibility to heavy metal poisoning
  • Application of mt-2a gene snp site in detection of susceptibility to heavy metal poisoning

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Embodiment 1

[0054] Embodiment 1. The newly discovered SNP site on the MT-2A gene is related to the susceptibility to heavy metal (cadmium) poisoning (case-control analysis)

[0055] 1. Taking the Chinese Han workers who were exposed to cadmium-polluted working environment for more than one year as the research object, according to the national occupational chronic cadmium poisoning diagnostic standard GBZ3-2006, the people who were diagnosed with chronic cadmium poisoning with mild or above as the case group (i.e. cadmium poisoning susceptibility group), and the people without any symptoms of cadmium poisoning were used as the control group. After statistical analysis, there was no significant difference in age, gender, and working years between the two groups (P>0.05).

[0056] 2. Detect the genotypes of the SNP site g.178 (G>A) of the above-mentioned case group (i.e. the cadmium poisoning susceptibility group) and the control group, and use the known SNP site g .47 (A>G) (the 47th posi...

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Abstract

The application discloses the application of the MT-2A gene SNP site in the detection of susceptibility to heavy metal poisoning. The SNP site is G>A at the 178th nucleotide of the MT‑2A gene, and the sequence of the MT‑2A gene is shown in SEQ ID No.7. The G and A of the SNP loci are significantly different between the case group and the control group, wherein, G is a cadmium poisoning susceptible allele or a cadmium poisoning high risk allele, and A is a non-cadmium poisoning susceptible allele Genes or low-risk alleles for cadmium toxicity. Therefore, by detecting the base type of this site, judging the genotype of this site can be used to detect heavy metal (such as cadmium) poisoning susceptibility or heavy metal poisoning risk, screen patients with heavy metal poisoning, identify or assist in the identification of heavy metal poisoning susceptibility genes, Detection of single nucleotide polymorphisms associated with heavy metal toxicity or metabolism. The applications and products provided by the invention are of great value in the identification of susceptible groups to heavy metal poisoning, thereby reasonably preventing heavy metal poisoning.

Description

technical field [0001] The invention belongs to the technical field of biomedical molecular detection, and specifically relates to the application of MT-2A gene SNP sites in detecting heavy metal poisoning susceptibility. Background technique [0002] The original meaning of heavy metals refers to metals with a specific gravity greater than 5 (generally speaking, metals with a density greater than 4.5 grams per cubic centimeter), including gold, silver, copper, iron, mercury, lead, cadmium, etc. Heavy metals accumulate in the human body to a certain extent. Can cause chronic poisoning. The heavy metals mentioned in terms of environmental pollution mainly refer to heavy elements with significant biological toxicity such as mercury (mercury), cadmium, lead, chromium, and metalloid arsenic. Heavy metals are very difficult to be biodegraded. On the contrary, they can be enriched by hundreds of times under the biomagnification of the food chain, and finally enter the human body....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 叶秀峰刘文兰徐迹孙波张晓丽唐婕赵卫华
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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