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Recombinant human-like collagen gel dressing for wounds, preparation method and use method thereof

A human collagen and protoprotein technology, applied in the field of bioengineering, can solve the problems of unfavorable promotion and application, high production cost, and achieve the effects of moisturizing the environment, preventing uneven coverage, and excellent water absorption and water retention performance.

Active Publication Date: 2019-04-05
常州市中辉医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production cost of this product is high, and transportation and storage require liquid nitrogen freezing. These conditions make the transfected pigskin a high-cost skin wound covering, which is not conducive to the promotion and application of this product.

Method used

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  • Recombinant human-like collagen gel dressing for wounds, preparation method and use method thereof
  • Recombinant human-like collagen gel dressing for wounds, preparation method and use method thereof
  • Recombinant human-like collagen gel dressing for wounds, preparation method and use method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This embodiment 1 provides a recombinant human collagen gel dressing, including: a regenerative agent and a cross-linking agent; and a cross-linking reaction between the two is suitable for forming a hydrogel state on the wound surface.

[0028] Optionally, the regeneration agent includes by weight: recombinant human collagen: 5-30 parts; CaCl 2 : 1-10 parts, and H 2 O: 65-95 parts.

[0029] Optionally, the cross-linking agent includes by weight: recombinant human collagen: 5-30 parts; sodium alginate: 0.5-5 parts, and H 2 O: 65-95 parts. Wherein the sodium alginate and CaCl 2 Cross-linked after mixing, that is, a cross-linked hydrogel state is formed on the wound surface. Specifically, when the regeneration agent is mixed with the crosslinking agent, Ca 2+ Cross-linking reaction occurs with sodium alginate, promotes the cross-linking of sodium alginate, and forms a cross-linked hydrogel state on the surface of the wound, so that the gel can maintain a certain shap...

Embodiment 2

[0038] The recombinant human collagen gel dressing of the present application not only includes the embodiment described in Example 1, but also other embodiments, as shown in Table 1 and Table 2. Due to limited space, only the main components and their contents are listed in Table 1 and Table 2. For the mechanism of action, refer to Example 1, which will not be repeated here. Among them, Table 1 lists the main components and contents of the regeneration agent and crosslinking agent, and Table 2 lists the main components and contents of the pH buffer salt system.

[0039] Table 1 Main components and content of recombinant human collagen gel dressing

[0040]

[0041] The unit of each component in Table 1 is kg.

[0042] Table 2 Main components and content of pH buffer salt system

[0043] Implementation

[0044] The unit of each component in Table 1 is mmol / L.

Embodiment 3

[0046] On the basis of Example 2, this Example 3 provides a comparative test of the recombinant human collagen gel dressing and the gene-transfected pigskin acting on the wound respectively. Figure 1a , Figure 1b and Figure 1c The comparison shows that the recombinant human collagen gel dressing and the gene transfected pigskin act on the patient's wound surface in the early stage of application (1-2 days), mid-term application (3-5 days) and wound healing (5-7 days). ) schematic diagram. It can be seen that if Figure 1a As shown, compared with the transgenic pig skin area 2 (the wound area using the transfected pig skin), the collagen gel area 1 (the wound area covered with the recombinant human collagen gel dressing) only needs the recombinant human collagen gel dressing The regenerative agent and the cross-linking agent are respectively applied on the surface of the wound, so that the two can form a hydrogel state, and then the surface of the hydrogel can be covered with...

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Abstract

The invention belongs to the field of bioengineering and specifically relates to a recombinant human-like collagen gel dressing for wounds, a preparation method and a use method thereof. The recombinant human-like collagen gel dressing comprises a regenerating agent and a cross-linking agent; the regenerating agent and the cross-linking agent are suitable for taking part in a cross-linking reaction so as to form a hydrogel state on wound surface; a special spraying device is used for spraying on wounds simultaneously and preventing a part of wounds from being uncovered or exposed and the recombinant human-like collagen gel dressing from being unevenly coated; hydrogel is similar to extracellular matrix in matrix, has excellent water-absorbing and water-retaining properties and high air permeability and is capable of supplying a humid repairing environment to wounds.

Description

technical field [0001] The invention relates to bioengineering, in particular to a recombinant human collagen gel dressing for skin wounds and a preparation method and application method thereof. Background technique [0002] Allogeneic skin is the best covering for skin wounds. However, due to the extremely scarce sources of body donations, high requirements for source, preparation, storage, and management, and high cost for patients, allogeneic skin cannot be promoted. application. [0003] Now skin wounds are usually transfected with pig skin, which has similar application range and physical properties compared with the classic biological dressing for traditional burns - allogeneic skin, and has a positive therapeutic effect on burn wounds of different depths; in addition, gene transfection As a standardized production product, dyed pigskin has smaller batch-to-batch variances than allogeneic skins, but larger than non-biological dressings. However, the production cost ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0033A61L26/008C08L5/04
Inventor 李海航钱松梁亮朱世辉
Owner 常州市中辉医疗器械有限公司
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