Evaporation and drying device for paclitaxel liposome

A technology of evaporative drying and liposomes, which is applied in the field of evaporative drying devices for paclitaxel liposomes, can solve problems such as easy leakage accidents, achieve the effects of reducing leakage accidents, ensuring compaction effect, and increasing weight

Active Publication Date: 2021-03-23
CHONGQING MEDICAL & PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide an evaporation and drying device for paclitaxel liposomes, which solves the problem that in the prior art, the rotary bottle and the steam tube are only sealed by the contact of their respective rubber sealing layers, which is prone to leakage accidents

Method used

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  • Evaporation and drying device for paclitaxel liposome
  • Evaporation and drying device for paclitaxel liposome
  • Evaporation and drying device for paclitaxel liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Basic as attached Figures 1 to 3 Shown:

[0032] The evaporative drying device of paclitaxel liposome comprises frame in the prior art, processing table, water bath 1, rotary bottle 4, bottle clamp 3, steam pipe 2 and two rubber sealing layers 21; water bath 1 and frame All are located on the processing table, and the steam pipe 2 is positioned on the frame. In order to facilitate the insertion of the steam pipe 2 into the rotary bottle 4, the diameter of the mouth of the steam pipe 2 is less than the diameter of the steam pipe 2 body. The outer wall of the nozzle of the steam pipe 2 is glued with a rubber sealing layer 21 . The bottle neck inner wall of the rotary bottle 4 is also bonded with a rubber sealing layer 21. When the steam pipe 2 is inserted into the rotary bottle 4, the two rubber sealing layers 21 are in contact with each other, thereby realizing the sealing of the two; and the rotary bottle 4 can be stretched into In the water bath 1, the water in the ...

Embodiment 2

[0039] The difference between this embodiment and Embodiment 1 is that the connecting strip 33 is a deformable elastic material, such as Figure 4 As shown, the connecting strip 33 is provided with a cavity 331, and the cavity 331 is provided with a soft bag 332. The soft bag 332 in this embodiment can be a thicker PVC plastic bag, and its outer wall is wrapped with a cotton cloth layer; the soft bag 332 Both sides are bonded to the cavity wall of the cavity 331; a metal strip 333 is stuck on the soft bag 332, and the soft bag 332 is filled with supersaturated solution sodium acetate 3321 (note that it cannot be filled when filling); the entire connecting strip 33 is mainly It is formed by supporting the metal strip 333.

[0040] During use, the hot air in the water bath 1 gushes out from the gap 121, and the hot air contacts the connecting bar 33, and then heats the supersaturated solution sodium acetate 3321 in the connecting bar 33, and the supersaturated solution sodium ac...

Embodiment 3

[0042] In this embodiment, on the basis of Embodiment 2, a through hole is provided on the wall of the cavity 331, and the hot air in the water bath can enter the cavity 331 through the through hole, further speeding up the contact speed between the soft bag 332 and the hot air.

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Abstract

The invention relates to the technical field of liposome processing and specifically discloses an evaporation drying device for paclitaxel liposome. The evaporation drying device comprises a bottle clamp, an evaporation tube and a rubber sealing layer located on an outer wall of the evaporation tube; the middle or upper part of the rubber sealing layer is bulged outward so as to form a bulged ring; the bottle clamp comprises a first C-shaped clamping wall and a second C-shaped clamping wall located under the first C-shaped clamping wall; a connecting strip is arranged between the first C-shaped clamping wall and the second C-shaped clamping wall; a counterweight bulge is arranged on the inner side of the first C-shaped clamping wall. The scheme is capable of solving the problem in the prior art that leakage accident is likely to occur because the rotating bottle and the evaporation tube are sealed through the contact of respective rubber sealing layers.

Description

technical field [0001] The invention relates to the technical field of liposome processing, and specifically discloses an evaporation and drying device for paclitaxel liposomes. Background technique [0002] Paclitaxel is a natural secondary metabolite isolated and purified from the bark of the gymnosperm plant Taxus chinensis. It has been clinically verified to have good anti-tumor effects, especially for ovarian cancer, uterine cancer and breast cancer, which have a high incidence of cancer. There are special effects. [0003] The problems of paclitaxel injection include: 1. Toxicity and sensitization of the solvent; 2. Instability after dilution; 3. Compatibility changes. In order to alleviate the above problems, liposomes, a new drug delivery system, have been discovered through continuous research. Experiments have shown that paclitaxel liposome preparations have similar curative effects compared with injections, but have reduced toxicity and improved tolerance. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D1/24B01D1/22
Inventor 兰作平
Owner CHONGQING MEDICAL & PHARMA COLLEGE
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