Composition and kit for evaluating oocyte quality

A technology of oocytes and compositions, applied in the field of reproductive medicine, can solve the problems of inability to accurately reflect the functional state of oocytes, non-invasive and convenient morphological methods, and large subjective influence of observers

Inactive Publication Date: 2019-05-10
BEIJING OBSTETRICS & GYNECOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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Problems solved by technology

Morphological methods are non-invasive and convenient, but they lack the most suitable unified standard, cannot accurately reflect the functional state of oocytes, and are greatly influenced by the subjectivity of observers. The subjectivity between observers makes the relationship between oocytes and embryonic development show difference

Method used

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Embodiment Construction

[0024] The present invention will be further described in detail below through specific embodiments. Through these descriptions, the features and advantages of the present invention will become more apparent.

[0025] According to one embodiment of the present invention, there is provided a composition comprising N-acetyl-D-tryptophan and hypotaurine. According to one embodiment, said composition is used as a standard in an oocyte quality assessment system.

[0026] In the above-mentioned embodiment according to the present invention, the content or ratio of N-acetyl-D-tryptophan and hypotaurine in the composition is the same as that of N-acetyl-D-tryptophan and hypotaurine in normal human follicular fluid. The content or ratio of hypotaurine is roughly equal. In one embodiment, the composition consists of N-acetyl-D-tryptophan and hypotaurine. In another embodiment, the composition consists of N-acetyl-D-tryptophan, hypotaurine and a suitable solvent.

[0027] In the embo...

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Abstract

The invention provides a composition comprising N-acetyl-D-tryptophan and hypotaurine and a kit for evaluating oocyte quality. The kit is used as a standard in an oocyte quality evaluating system, andthe quality of oocyte is evaluated by comparing the contents of the N-acetyl-D-tryptophan and the hypotaurineand in follicular fluid and corresponding components in the composition. The composition can be used as a basis for selecting high-quality oocyte for an IVF-ET technology, embryos with higher quality are obtained for transplantation, thereby increasing the pregnancy rate and reducing abortion, and the composition is of great significance for the birth of healthy offspring. Compared with existing morphological evaluation methods, the composition and the kit can be used for achieving non-invasive, objective and convenient oocyte quality evaluation.

Description

technical field [0001] The invention relates to the field of reproductive medicine, in particular to a composition and a kit for evaluating the quality of oocytes. Background technique [0002] 1. Infertility and Assisted Reproductive Technology [0003] Infertility patients in my country have accounted for 12.5% ​​of the population of childbearing age, and the number has exceeded 40 million, showing a trend of rapid growth. Assisted reproductive technology (assisted reproductive technology, ART) has brought hope for infertility patients to give birth to new life bodies. However, in in vitro fertilization (in vitro fertilization, IVF), nearly 80% of embryos fail to implant. In order to improve the success Multiple embryo transfers are carried out in various reproductive centers, resulting in an increase in multiple pregnancies, and complications such as premature birth, stillbirth, low birth weight, birth defects, and mother's high blood pressure in multiple pregnancies are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/02
Inventor 阴赪宏王程荣代荫梅岳文涛杨晓葵洪黎明
Owner BEIJING OBSTETRICS & GYNECOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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