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Medicinal material of polygonum capilalum, extractive, and quality control method

A detection method, the technology of Polygonum cephalum, is applied in the directions of medical formula, material inspection products, material separation, etc., and can solve the problems of incomplete quality control indicators and other issues

Inactive Publication Date: 2009-09-02
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is not comprehensive to use quercetin only as a quality control index for Polygonum cephalum with complex components

Method used

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  • Medicinal material of polygonum capilalum, extractive, and quality control method
  • Medicinal material of polygonum capilalum, extractive, and quality control method
  • Medicinal material of polygonum capilalum, extractive, and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 medicine of the present invention

[0034] [Preparation method] Cut Polygonum cephalosporin into sections, add water to boil twice, each time for 1.5 hours, combine the decoction, let it stand, filter, the filtrate is concentrated into a thick paste, dry, crush, add appropriate amount of auxiliary materials, mix well, and pack into capsules , that is.

[0035] 【Properties】This product is a capsule, the content is brown powder; slightly gas, slightly astringent taste.

[0036][Identification] Take 3g of this product, add 20ml of methanol, reflux in water bath for 1 hour, filter, concentrate the filtrate to about 2ml, put it on an alumina column (3g of neutral alumina, 100-200 mesh, dry at 105°C for 30 minutes, and the inner diameter of the column is 1cm ), elute with methanol 50ml, collect the eluate, concentrate to about 1ml on a water bath, and use it as the test solution. Take another 1.5g of Polygonum cephalum reference medicinal mat...

Embodiment 2

[0040] The preparation of embodiment 2 pharmaceutical granules of the present invention

[0041] [Preparation method] Take 1000g of Polygonum cephalosporin, add water and decoct twice, each time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to a thick paste with a relative density of 1.38 (80°C), dry, crush, and make granules. Dry to make 400g, or add appropriate amount of sucrose powder, mix well, make granules, dry to make 800g, that is.

[0042] 【Properties】This product is tan to dark brown granules; fragrant, sweet and slightly astringent.

[0043] [Identification] Take 3g (sugar-free type) or 6g (sugar-containing type) of this product, add 20ml of methanol, reflux in water bath for 1 hour, filter, concentrate the filtrate to about 2ml, and add it to an alumina column (neutral alumina 3g, 100-200 mesh, dry at 105°C for 30 minutes; the inner diameter of the column is 1cm), elute with 50ml of methanol, collect the eluate, concentrate on a water ...

Embodiment 3

[0052] Embodiment 3 The present invention controls the method for Polygonum cephalum medicinal material

[0053] 1. Experimental materials and instruments

[0054] 1. Medicinal materials

[0055] Collected from Guizhou, Sichuan, Yunnan, and Tibet, a total of 15 batches were identified as the dried whole herb of Polygonum capitatum Buch.-Ham.ex D.Don by Professor Wan Deguang of Chengdu University of Traditional Chinese Medicine. Polygonum capitulum is the dried whole herb of Polygonum nepalense Meisn, a plant of the Polygonaceae family, collected from Mount Emei, Sichuan.

[0056] 2. Instruments and reagents

[0057] Waters2695 high performance liquid chromatography, diode array detector, Empower chromatography workstation, SB2200 ultrasonic cleaner. Gallic acid reference substance (National Institute for the Control of Pharmaceutical and Biological Products, batch number: 0638-9501), quercetin reference substance (National Institute for the Control of Pharmaceutical and Bio...

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Abstract

The present invention provides Polygonum cephalum medicinal material, which has an HPLC fingerprint as shown in Figure 1D, containing 13 characteristic peaks, wherein the chromatographic conditions are: chromatographic column: Elite Hypersil ODS chromatographic column (4.6mm × 150mm, 5 μm) ;Column temperature: 25°C; Mobile phase: acetonitrile (A)-0.4% phosphoric acid (B) solution binary gradient elution, weight percentage: 0-30%: 100-70%; flow rate: 0.8mL min-1 ; Detection wavelength: 310nm; Injection volume: 20μl. The invention also provides the extract and its quality control method. The quality control method of the present invention investigates and compares Polygonum cephalosporins from different origins, constructs the HPLC fingerprints of Polygonum cephalosporins, and uses the HPLC fingerprint features to comprehensively monitor the quality of Polygonum cephalosa medicinal materials to ensure that it is stable, uniform, controllable, and effective. Control the quality of medicinal materials accurately, and achieve the purpose of controlling the entire pharmaceutical preparation.

Description

technical field [0001] The invention relates to Polygonum cephalum medicinal material and its extract and quality control method. Background technique [0002] Polygonum capitatum is the dry whole grass or the aerial part of Polygonum capitatum Buch.-Han.ex D.Don of the Polygonaceae plant. Polygonum cephalosporin is used as medicine. It was first recorded in the 1963 edition of "Guangxi Traditional Chinese Medicine", and it was called Shimangcao and Polygonum shimangi. "Guangxi Chinese Herbal Medicine" records that its taste is "bitter, pungent, and flat in nature", detoxifies and reduces inflammation, and treats dysentery, skin ulcers, and unknown swelling. "Yunnan Chinese Herbal Medicine" calls it Sungrass, which is sour in taste and cool in nature. Heat-clearing and diuretic, treating stranguria, controlling hematuria, cystitis. "Wenshan Chinese Herbal Medicine" calls it Mandihong and Huoliucao, which can treat brucellosis and yellow water sores. "Guizhou Chinese Herb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N33/15A61K36/70A61P13/00
Inventor 万德光王祥培
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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