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Compositions comprising a cannabinoid receptor binding ligand

A kind of cannabinoid receptor and composition technology, applied in the field of ophthalmic preparations

Inactive Publication Date: 2019-05-24
NOVALIQ GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, preservatives available in ophthalmic preparations can be harmful to the eye, especially the ocular surface, and should be avoided in cases of dry eye disease

Method used

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  • Compositions comprising a cannabinoid receptor binding ligand
  • Compositions comprising a cannabinoid receptor binding ligand
  • Compositions comprising a cannabinoid receptor binding ligand

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0125] Preparation of a formulation comprising a cannabinoid receptor binding ligand :

[0126] Preparation of THC preparations:

[0127] By dissolving 7.546 mg of dronabinol (THC Pharm GmbH, Frankfurt, Germany) preheated to 55° C. for 5 minutes in 7.55 ml of 1-perfluorobutyl-pentane (F4H5) in a glass vial, A stock solution of delta-9-tetrahydrocannabinol (THC) at a concentration of 1 mg / ml was prepared. 5 ml of a THC preparation with a THC content of 0.5 mg / ml was obtained by adding 2.5 ml of F4H5 (1 mg / ml) to 2.5 ml of THC stock solution. 5 ml of a THC preparation at a concentration of 0.1 mg / ml was obtained by adding 4.5 ml of F4H5 (1 mg / ml) to 0.5 ml of THC stock solution. A clear solution of 1-perfluorobutyl-pentane containing 0.1 mg / ml, 0.5 mg / ml or 1 mg / ml THC was placed in a closed box and stored at room temperature. A stock solution of delta-9-tetrahydrocannabinol (THC) at a concentration of 5 mg / ml was thus prepared.

[0128] Preparation of β-caryophyllene prep...

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Abstract

The present invention provides a pharmaceutical composition comprising: a) a therapeutically effective amount of at least one cannabinoid receptor binding ligand, and b) a liquid vehicle comprising atleast one semifluorinated alkane; as well as the use of such pharmaceutical compositions as a medicament.

Description

Background technique [0001] Keratoconjunctivitis sicca, also known as dry eye disease or dysfunctional tear syndrome, is today recognized as a multifunctional condition of the tear film and ocular surface that causes discomfort, visual disturbance, and often even Damage to the ocular surface. Its prevalence varies by region and is estimated to be approximately 7.4% in the United States and 33% in Japan (J.L. Gayton, Clinical Ophthalmology 2009: 3, 405-412). According to another estimate, approximately 3.2 million women and 1.05 million men have keratoconjunctivitis sicca in the United States alone. If cases with mild symptoms are also taken into account, there could be as many as 20 million infected people in the United States. [0002] The primary physiological function of the tear film is to lubricate the ocular surface and inner eyelid. In addition, it provides the ocular surface with the nutrients it needs, giving the eye a smooth and regular optical surface. Furthermo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K31/025A61P27/02
CPCA61K31/025A61K31/353A61P27/02A61P27/04A61K2300/00A61K9/10A61K9/08A61K9/0048A61K31/352A61K31/02
Inventor 伯恩哈德·金特弗兰克·洛施尔索尼娅·克罗斯尔菲利普·史蒂文
Owner NOVALIQ GMBH