Method for extracting and preparing arthritisChinese patent medicine from ginger

A technology for arthritis and Chinese patent medicines, which is applied in the field of extracting and preparing Chinese patent medicines for arthritis diseases from ginger, which can solve the problems that extracts are difficult to prepare, and raw materials, extracts and finished preparations are not proposed or formulated.

Inactive Publication Date: 2019-05-28
雷萌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are multiple Chinese medicine preparations for the treatment of (like) rheumatoid arthritis. They all have a good effect on treating internal rheumatism, can control the disease, and relieve symptoms, but there are still deficiencies: first, the effective parts (active ingredients) of Chinese medicines The problem of extraction, separation and preparation methods, because they are the material basis for the efficacy of traditional Chinese medicine and the bottleneck of the modernization of traditional Chinese medicine
However, traditional processes such as soaking, decoction, and percolation are still used at present, making it difficult to prepare the extracts into effective parts (active ingredients) with quantitative indicators; followed by quality standards, anti-rheumatic Chinese patent medicines are mostly compound preparations or traditional Chinese medicines In bold, no quality standards have been proposed or established for the control of raw materials, extracts and finished preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: The effective fraction volatile oil and 6-Gingerol of ginger are prepared by pressing method

[0019] Take ginger, remove impurities, and press with a press for 3 hours to obtain crude ginger oil, wherein the content of volatile components is 67%, and the content of 6-Gingerol is 0.1-5%.

Embodiment 2

[0020] Embodiment 2: adopt solvent method to prepare the effective part of ginger

[0021] (1) cold immerse twice with petroleum ether or gasoline, each time for 24 hours, add 6 times the amount of solvent each time, get crude oil, filter, get ginger oil, wherein the content is 92% if the volatile component is the effective part , with 6-Gingerol as the active ingredient content up to 1.2%.

[0022] (2) Petroleum ether or gasoline reflux extraction 3 times, 2 hours each time, add 4 times the amount of solvent each time, to obtain crude oil, filter, to obtain ginger extract, wherein the content is 80% if the volatile components are the effective parts , with 6-Gingerol as the active ingredient content up to 2.0%.

Embodiment 3

[0023] Embodiment 3: adopt supercritical carbon dioxide extraction method to prepare the volatile component of ginger and 6-Gingerol

[0024] Using supercritical carbon dioxide extraction method, extract twice, the first time pressure 35Mpa, temperature 30°C, time 2 hours, the second time pressure 40Mpa, temperature 40°C, time 3 hours, to get crude oil, filter to get ginger extract , wherein the content is 89% when the volatile component is the effective part, and the content reaches 4.6% when the active component is 6-Gingerol.

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PUM

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Abstract

The invention provides a method for extracting and preparing an arthritisChinese patent medicine from ginger. The method is mainly characterized in that the arthritisChinese patent medicine is prepared by an extract of the ginger (fresh ginger and dry ginger), and content of an effective part (consisting of volatile components) in the extract is greater than 50%; the medicine has the effects of warming and activating merdian, resisting inflammation and alleviating pain and the like, and is used for preventing and treating (rheumatoid) rheumatic arthritis; and content of an effective part of apreparation prepared by the extract is greater than 50%. A preparation method for the extract is characterized by comprising a squeezing method, a steam distillation method (comprising a co-water distillation method), a supercritical carbon dioxide extraction method, an organic solvent extracting method, a water-adding grinding method and a column chromatography method. The extract thereof can beprepared as any medical dosage forms, and applied for preparing the medicine for preventing and treating rheumatism. The medicine composition is capable of overcoming limitation that most of the medicines for treating the rheumatism are a crude medicine single-prescription or compound-prescription water decoction preparation of the traditional medicines, and providing a pure traditional Chinese medicine modern pharmaceutical preparation with exact curative effect, safety and convenience, small side effect, and low price and a preparation technology.

Description

technical field [0001] The invention relates to a method for extracting and preparing Chinese patent medicine for arthritis from ginger. Background technique [0002] Because most arthritis is one of the early symptoms of rheumatic fever, rheumatic fever is also called rheumatic arthritis clinically. At present, 91.7% of adults and 55.7% of children are affected by their joints in the world, and the number of disabled and dead due to its lesions ranks at the forefront of the world's epidemics. Rheumatoid arthritis not only causes serious physical and mental harm to patients, but also has a huge economic burden on individuals and society. According to the analysis and statistics of IMS, in 2000, the global cost of treating rheumatoid arthritis reached 53.7 billion yuan, an increase of 8% compared with 1999. With the development of society and economy, the accelerated pace of life, the increase of mental stress and social competition, the incidence of such diseases is still ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P19/02A61P29/00
Inventor 雷萌
Owner 雷萌
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