Micronized roxatidine acetate pharmaceutical salt pellets and preparation method and applications thereof

A technology of roxatidine acetate and salt pellets, which is applied in the direction of pharmaceutical formulations, medical preparations containing no active ingredients, and medical preparations containing active ingredients, etc. The problem of low drug loading in the layer coating can achieve good stability and improve the effect of sustained release.
CN109833299AActive Publication Date: 2019-06-04北京轩升制药有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
北京轩升制药有限公司
Publication Date
2019-06-04

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Abstract

The invention relates to micronized roxatidine acetate pharmaceutical salt pellets. The pellets comprise a blank pellet core and a drug-loading layer, wherein the drug-loading layer contains micronized rosatidine acetate pharmaceutical salt, the rosatidine acetate pharmaceutical salt can improve the actual content of active ingredients in the drug-loading pellets after micronization treatment, thetechnical problem that the actual drug-loading amount of the drug-loading coating is relatively low, and the content stability of a final product is improved.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations. Specifically, the invention relates to a roxatidine acetate pharmaceutical salt pellet, a preparation method thereof and an application thereof. Background technique

[0002] Roxatidine aidcetate hydrochlore (ROX) is another H 2 A selective antagonist of the receptor, it can block the histamine H2 receptor of the parietal cell of the gastric mucosa to show continuous inhibition of gastric acid secretion, and also has mucosal protection. It is clinically suitable for the treatment of peptic ulcer disease and has moderate acid suppression ideal drug. Compared with proton pump inhibitors (PPI), roxatidine acetate hydrochloride has many clinical advantages: ① It acts on the histamine activation pathway, moderately inhibits gastric acid secretion, and has a definite preventive effect on stress ulcers in hospitalized patients , effectively prevent and treat stress ulcers, and its preventive...

Claims

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