Cistanche deserticola extract and preparation method and application thereof

An extract of Cistanche deserticola and the technology of the extract are applied in the direction of medical formula, drug combination, plant raw materials, etc., and can solve the problems of not clearly specifying the main ingredients and composition of laxatives, cumbersome process, and increased production energy consumption.

Active Publication Date: 2019-06-21
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Patent CN101353360A discloses an extract of Cistanche deserticola and its preparation method and use, but the patent does not clearly point out the main components and composition of laxatives, and the patent uses water to extract Cistanche deserticola, Cistanche deserticola polysaccharides and other large The molecular components are then extracted, and then the extract of Cistanche deserticola is refined by alcohol precipitation process, which is relatively cumbersome and increases the energy consumption of production

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  • Cistanche deserticola extract and preparation method and application thereof
  • Cistanche deserticola extract and preparation method and application thereof
  • Cistanche deserticola extract and preparation method and application thereof

Examples

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preparation example 1

[0025] Take Cistanche medicinal material (dried succulent stem with scaly leaves of Cistanche diserticola Y.C.Ma), crush to 24 mesh, add 70% ethanol solution of 10 times the amount of medicinal material and extract under reflux for 2 hours, the extraction temperature is 75-80°C, and the extraction times are 3 Once, the filtrates were combined, and the filtrates were for subsequent use; the above-mentioned filtrates were concentrated under reduced pressure to no alcohol smell, and centrifuged to obtain a concentrated solution with a relative density of 1.01kg / L; the concentrated solution was placed at room temperature and passed through an ADS-17 macroporous resin column (Zhengzhou Qinshi Technology Co., Ltd.), eluted with purified water, the amount of eluent was 5 times the column volume, collected water eluate, and concentrated under reduced pressure to obtain a concentrated solution with a relative density of 1.20kg / L, that is, the active extract of Cistanche deserticola , th...

preparation example 2

[0026] Take Cistanche medicinal material, crush it to 60 mesh, add 65% ethanol solution 20 times the amount of medicinal material, reflux and extract for 2 hours, the extraction temperature is 80-85°C, the extraction times are 4 times, the filtrate is combined, and the filtrate is set aside; the above-mentioned filtrate is concentrated under reduced pressure Centrifuge until there is no alcohol smell, and obtain a concentrated solution with a relative density of 1.02kg / L; place the concentrated solution at room temperature, pass through an AB-8 macroporous resin column (Zhengzhou Qinshi Science and Technology Co., Ltd.), and elute with purified water. The amount of dehydration is 4 times the column volume, the water eluate is collected, and concentrated under reduced pressure to a relative density of 1.23kg / L to obtain the active extract of Cistanche deserticola. The total oligosaccharide content in the extract is 39.2%, mannitol content of 25.0%, betaine content of 22.1%. Pre...

preparation example 3

[0027] Take Cistanche medicinal material, crush it to 30 mesh, add 20 times the amount of medicinal material in 60% ethanol solution to reflux extraction for 4 hours, the extraction temperature is 85-90°C, the extraction times is 2 times, the filtrate is combined, and the filtrate is set aside; the above filtrate is concentrated under reduced pressure Centrifuge until there is no alcohol smell, and obtain a concentrated solution with a relative density of 1.03kg / L; place the concentrated solution at room temperature, pass through an ADS-17 macroporous resin column (Zhengzhou Qinshi Science and Technology Co., Ltd.), and elute with purified water. The amount of dehydration is 6 times the column volume, the water eluate is collected, concentrated under reduced pressure to a relative density of 1.25kg / L, and the active extract of Cistanche deserticola is obtained. The total oligosaccharide content in the extract is 21.1%, mannitol The content of betaine is 6.8%, and the content of...

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Abstract

The invention discloses Cistanche deserticola extract and a preparation method and application thereof. The preparation method has the advantages that the preparation method is simple in process, easyto operate and low in cost, the oligosaccharide content in the obtained extract is about 20-40%, the mannitol content of the obtained extract is about 5-25%, and the betaine content of the obtained extract I s 10-30%; the extract has an effect of relaxing bowels, can enhance the intestine propulsion function, shorten defecation time, increase defecation total quantity, lower colonic myoelectricity amplitude, increase myoelectricity creep frequency or increase the c-kit positive expression in colon Cajal mesenchymal cells, and can evidently improve colon tissue inflammation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an extract of Cistanche deserticola and its preparation method and application. Background technique [0002] Constipation is a symptom of many diseases. With the development of the economy, the deterioration of the ecological environment and the acceleration of people's life rhythm, about 5.0% to 10.0% of the intestinal outpatients come to see a doctor because of constipation. Currently domestic and foreign clinical treatment of constipation mainly through the following approaches: 1, drug treatment should be based on the principles of low toxicity, small side effects, and small drug dependence, such as bulking agents and osmotic laxatives. Agonists may be added for slow transit constipation. For fecal impaction, cleansing enema once or short-term combined with stimulant laxatives to relieve impaction. Use bulking agents or osmotic laxatives after relief....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/64A61P1/10A61P29/00
Inventor 萧伟屠鹏飞殷洪梅高云佳常秀娟石子仪徐忠坤胡晗绯周军吴云王振中
Owner JIANGSU KANION PHARMA CO LTD
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