Coating and material to promote vascular intimal repairing, preparation method of material and medical product

A technology of vascular intima and coating, which is applied in the field of biomedical materials, can solve the problems of non-specific performance in promoting endothelial cell adhesion, and achieve the effect of promoting endothelial cell viscosity, promoting repair, and promoting adhesion
CN109966565AInactive Publication Date: 2019-07-05SOUTHWEST JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTHWEST JIAOTONG UNIV
Publication Date
2019-07-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of biomedical materials and provides coating to promote vascular intimal repairing. An amino-containing polypeptide and a copper-based MOF (metal-organic framework)are grafted to the surface of the coating; the amino-containing polypeptide is capable of specifically promoting adhesion of endothelial cells. A material to promote vascular intimal repairing comprises a substrate material; the coating to promote vascular intimal repairing is attached to the surface of the substrate material. A preparation method of the material to promote vascular intimal repairing comprises coating the surface of the substrate material with the copper-based MOF and the coating which the amino-containing polypeptide is grafted to; the amino-containing polypeptide can specifically promote adhesion of the endothelial cells; a medical product is made with the above material to promote vascular intimal repairing. All the coating, the material and the medical product providedherein can specifically promote adhesion and growth of endothelial cells, and reduce damage to the endothelial cells in a peroxidation micro environment.
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Description

technical field

[0001] The invention relates to the field of biomedical materials, in particular to a coating, a material, a preparation method of the material and a medical product for promoting vascular intima repair. Background technique

[0002] At present, forming a complete endothelialized layer on the surface or promoting the in situ repair of the intima to obtain excellent blood compatibility and tissue compatibility is the research goal of biomaterials in contact with blood, and has become a research hotspot in this field. The existing technology promotes the adhesion, proliferation and migration of endothelial cells on the material surface by immobilizing or grafting vascular growth factors, target genes and polypeptide sequences on the material surface. In the study, peptides with specific endothelial cell adhesion promotion, such as REDV, CAG, etc., were immobilized on the surface of the material. The grafting of peptides promoted the adhesion of endothelial cell...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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