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Chrysanthemum Leaf Extract and Its Application for Preventing and Preventing Liver Damage

An extract and liver damage technology, applied in the field of chrysanthemum leaf extract and its application in the preparation of liver damage prevention drugs and health care products, can solve the problems of unrelated research and achieve strong operability, no toxic side effects, Environmentally friendly effect

Active Publication Date: 2022-03-11
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no relevant research on how to conduct systematic research on chrysanthemum leaves, especially how to apply them to the development of drugs and health products for the prevention and treatment of liver damage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1, a kind of preparation method with the active extract of chrysanthemum leaf that prevents and treats liver damage, it comprises the following steps:

[0039] (1) Take fresh chrysanthemum leaves, dry them in the shade, crush them appropriately, place them in an extraction tank, add 95% ethanol with a volume 15 times the weight of the medicinal materials, heat and reflux for extraction 3 times, each time for 1 hour, filter and combine the extracts, and decompress After recovering the ethanol until there is no alcohol smell, the chrysanthemum leaf alcohol extraction extract is obtained and set aside;

[0040] (2) Take the ethanol extract extract obtained in step (1), add 10 times the volume of water to suspend evenly, add 10 times the volume of n-hexane to extract once, and take the remaining liquid after extraction for subsequent use;

[0041] (3) Take the remaining liquid after the extraction of chrysanthemum leaves obtained in step (2), put it on a polyamide column wi...

Embodiment 2

[0045] 1, a kind of preparation method with the active extract of chrysanthemum leaf that prevents and treats liver damage, it comprises the following steps:

[0046] (1) Take fresh chrysanthemum leaves, dry them in the sun, crush them, put them into an extraction tank, add 20 times, 15 times, and 10 times the volume of 95% ethanol in turn, heat and reflux extraction for 3 times, each time for 1 hour, and filter 1. Merge the extracts, recover the ethanol under reduced pressure until there is no alcohol smell, and obtain the chrysanthemum leaf alcohol extract, which is set aside;

[0047] (2) Take the ethanol extract extract obtained in step (1), add 15 times the volume of water to suspend evenly, add successively 20 times, 15 times, and 10 times the volume of cyclohexane to extract 3 times, and take the remaining Liquid standby;

[0048] (3) Take the remaining liquid after the extraction of chrysanthemum leaves obtained in step (2), put it on a polyamide column with a particl...

Embodiment 3

[0052] 1, a kind of preparation method with the active extract of chrysanthemum leaf that prevents and treats liver damage, it comprises the following steps:

[0053] (1) Take fresh chrysanthemum leaves, remove impurities, dry them with hot air at 45°C and crush them appropriately, put them into an extraction tank, add 95% ethanol in order of 20 times, 15 times, and 10 times the volume of the medicinal material, heat and reflux for 3 times, and then 2 hours, 1.5 hours, 1 hour. Filter and combine the three extracts, recover the ethanol under reduced pressure until there is no alcohol smell, and obtain the chrysanthemum leaf alcohol extract, which is set aside;

[0054] (2) Get the chrysanthemum leaf alcohol extraction extract obtained in step (1), add 15 times of water to suspend evenly, add successively 10 times, 8 times, and 6 times of methylene chloride for extraction, and take the remaining liquid after extraction, spare;

[0055] (3) take the remaining liquid after the e...

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Abstract

The invention discloses a chrysanthemum leaf extract capable of preventing and treating liver damage and its application. The invention is mainly composed of the ethanol extract of the chrysanthemum leaf through organic solvent extraction and degreasing, macroporous adsorption resin and medium pressure chromatographic separation gel MCI enrichment and refinement , prepared through a large number of test screenings, non-toxic and side effects, healthy and safe, the experimental results show that the extract of the present invention can improve chemical liver damage caused by D-galactosamine and drug-induced liver damage caused by acetaminophen, significantly reducing Serum transaminase levels and lipid peroxidation damage increase the body's glutathione content, which has a protective effect on liver damage. The preparation method provided by the invention is simple and convenient, has a high degree of automation, can well retain active ingredients in raw materials, has no toxic and side effects, and can be used to prepare medicines and health care products for preventing and treating liver damage.

Description

technical field [0001] The invention relates to the comprehensive development and utilization of traditional non-medicinal parts of natural medicinal and edible homologous plants, in particular to a chrysanthemum leaf extract and its application in the preparation of liver injury prevention and treatment medicines and health care products. Background technique [0002] As the largest solid organ in the whole body and the main detoxification organ, the liver is responsible for important physiological functions of the human body, such as synthesis of liver glycogen and coagulation factors, foreign body metabolism, hormone metabolism, storage of fat-soluble vitamins, and bile production. Because the liver undertakes many physiological functions and its abundant blood flow, the liver is also vulnerable to the invasion and loss of various internal and external pathogenic factors. Depending on the etiology, liver injury mainly includes viral hepatitis (hepatitis B, hepatitis C, et...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/287A61P1/16A23L33/105A61K127/00
CPCA61K36/287A61P1/16A23L33/105A61K2236/333A61K2236/39A61K2236/55A23V2002/00A23V2200/32A23V2250/21A23V2300/14
Inventor 魏丹丹段金廒郭盛常相伟严辉钱大玮
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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