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Application of Aurora-B kinase to preparation of OSCC (Oral Squamous Cell Carcinoma) diagnostic kit

A technology for squamous cell carcinoma and diagnostic kits, which is applied in the preparation of test samples, biological tests, material inspection products, etc., and can solve the problems of no research reports on histological differentiation

Inactive Publication Date: 2019-09-10
GUILIN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the expression of Aurora-B kinase in OSCC tissues has not been determined, and there is no research report on the relationship between Aurora-B kinase protein expression and OSCC cell proliferation, histological differentiation and lymph node metastasis.

Method used

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  • Application of Aurora-B kinase to preparation of OSCC (Oral Squamous Cell Carcinoma) diagnostic kit
  • Application of Aurora-B kinase to preparation of OSCC (Oral Squamous Cell Carcinoma) diagnostic kit
  • Application of Aurora-B kinase to preparation of OSCC (Oral Squamous Cell Carcinoma) diagnostic kit

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Experimental program
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Embodiment 1

[0013] Materials and methods

[0014] Patient and Tissue Samples

[0015] Forty patients (26 males and 14 females) with oral squamous cell carcinoma (OSCC) were selected from the pathological archives of Hiroshima University Hospital in Japan and Peradeniya University in Sri Lanka, including 11 cases with lymph node metastasis. The age at diagnosis ranged from 23 to 86 years old (mean, 58.1 years old). According to the criteria of the Japan Head and Neck Cancer Society, 12 cases were benign, 19 cases were moderate, and 9 cases were poorly differentiated squamous cell carcinoma. In addition, 6 cases of normal oral mucosa were used as normal controls. For immunohistochemical examination, tissues were fixed in 10% buffered formalin and embedded in paraffin. After the antigen was repaired by microwave in citrate buffer (pH 6.0), immunohistochemical staining was carried out by Aurora-B kinase monoclonal antibody (Transducer, San Diego, California, USA, diluted 1:50), and the LSA...

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Abstract

The invention relates to the field of diagnosis and treatment of the OSCC (Oral Squamous Cell Carcinoma), and particularly relates to application of Aurora-B kinase to diagnosis on the OSCC. The invention solves a problem of providing application of the Aurora-B kinase to preparation of an OSCC diagnostic kit. Expression of the Aurora-B kinase is closely related to OSCC cell proliferation, multinuclear cell induction, histological differentiation and transfer, prompts the progress that the Aurora-B kinase participates in the OSCC, and prompts that the Aurora-B kinase can be used as a new diagnosis and treatment target for the OSCC.

Description

technical field [0001] The invention relates to the field of diagnosis and treatment of oral squamous cell carcinoma, in particular to the application of aurora-B kinase in the diagnosis of oral squamous cell carcinoma. Background technique [0002] Human solid tumors and many hematological malignancies are characterized by chromosomal instability (CIN), whole-chromosomal gain-loss rates, aneuploidy, and altered chromosome number status. Recent studies have clearly demonstrated that CIN and aneuploidy, long considered late progression events in established tumors, are in fact early molecular alterations as seen today. Oral squamous cell carcinoma (OSCC) is one of the most common cancer types in humans, with an annual incidence of more than 500,000 cases worldwide, seriously threatening human life. Aurora-B kinase (Aurora-B kinase), a chromosomal passenger protein, is critical for chromosome segregation and cell division, localized at the centromere at the transition from pr...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/68G01N1/30
CPCG01N1/30G01N33/5743G01N33/6863
Inventor 齐广莹秘思思杨小洁周紫惠周立华
Owner GUILIN MEDICAL UNIVERSITY
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