Application of butyric acid compounds in inhibiting long-chain non-coding RNA-H19

A RNA-H19, long-chain non-coding technology, applied in the field of food and medicine, to achieve the effect of preventing occurrence and development, preventing tissue and organ damage, and promoting disease progression

Inactive Publication Date: 2019-09-17
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of butyric acid compounds on long non-coding RNA-H19 has not been reported yet

Method used

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  • Application of butyric acid compounds in inhibiting long-chain non-coding RNA-H19
  • Application of butyric acid compounds in inhibiting long-chain non-coding RNA-H19

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] This example provides a long-chain non-coding RNA-H19 specific inhibitor containing butyric acid compounds and its preparation method. The method is as follows: adding food-grade or injection-grade sodium butyrate to the nutritional preparation and mixing evenly , that is. The concentration of sodium butyrate in the prepared nutritional preparation was 5mM.

Embodiment 2

[0040] This example provides a long-chain non-coding RNA-H19 specific inhibitor containing butyric acid compounds and its preparation method. The method is as follows: adding food-grade or injection-grade sodium butyrate to the nutritional preparation and mixing evenly , that is. The concentration of sodium butyrate in the prepared nutritional preparation is 50mM.

Embodiment 3

[0042] This example provides a long-chain non-coding RNA-H19 specific inhibitor containing butyric acid compounds and its preparation method. The method is as follows: adding food-grade or injection-grade glyceryl butyrate into the nutritional preparation, mixing Evenly, that is. The concentration of butyrin in the prepared nutritional preparation is 150mM.

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Abstract

The invention provides an application of butyric acid compounds in inhibiting long-chain non-coding RNA-H19. The butyric acid compounds are selected from at least one of butyric acid, butyrate and butyric acid derivatives. The effective concentration and the effective dose of the butyric acid compounds are 5-200 mM and 0.5-20 mmol/kg/d, respectively. For the first time, the invention finds that butyric acid compounds can be used as a specific inhibitor of long-chain non-coding RNA-H19, and can effectively inhibit abnormally elevated H19 in diseases. In a carbon tetrachloride model and a bile duct ligation model, the expression level of H19 is dozens of times higher than that in a normal group; after intervention with butyric acid compounds, the expression level of H19 is significantly reduced; and the butyric acid compounds are very effective in preventing the occurrence and development of diseases, and can effectively prevent and treat tissue and organ damage, fibrosis, canceration and many diseases due to various causes.

Description

technical field [0001] The invention relates to the technical field of food and medicine, in particular to the application of a butyric acid compound in inhibiting long-chain non-coding RNA-H19. Background technique [0002] H19 is the first long non-coding RNA discovered. The long non-coding RNA encoded by the H19 gene is normally underexpressed, but it is abnormally elevated in many diseases and has been proven to play an important role. H19 has the effect of accelerating tissue and organ damage, fatty degeneration, fibrosis, tissue sclerosis, etc. caused by various reasons, and is effective in various diseases such as metabolic diseases, obstructive diseases, non-alcoholic liver diseases, diabetes, and parenteral nutrition-related liver diseases. play an important role in injury. Abnormal expression of H19 is also considered to be closely related to a variety of tumors, such as liver cancer, lung cancer, malignant hematological diseases, breast cancer, cervical cancer, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/22A61P35/00A61P3/00A61P1/16A61P3/10A23L33/10
CPCA23V2002/00A61K31/19A61K31/22A23L33/10A61P1/16A61P3/00A61P3/10A61P35/00A23V2200/308A23V2200/328A23V2250/02A23V2250/30
Inventor 文洁蔡威张天周慧萍
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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