Monocyclic oga inhibitor compounds
A compound and selected technology, applied in organic chemistry, drug combination, nervous system diseases, etc., can solve problems such as cell cycle arrest and glycogen mobilization defects
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[0114] The present invention relates to a compound of formula (I), or a compound of formula (I'), and pharmaceutically acceptable addition salts and solvates thereof, for use as defined above. Compounds of formula (I) are inhibitors of O-GlcNAc hydrolase (OGA) and are useful for the prophylaxis or treatment of tauopathies, in particular tauopathies selected from the group consisting of: Alzheimer progressive supranuclear palsy, Down syndrome, frontotemporal dementia, frontotemporal dementia with parkinsonism-17, Pick's disease, corticobasal degeneration, and argyrophilic granular disease; or available For the prevention or treatment of neurodegenerative diseases associated with tauopathies, especially neurodegenerative diseases selected from amyotrophic lateral sclerosis or frontotemporal dementia caused by C9ORF72 mutations.
[0115] In a particular embodiment, the invention relates to compounds of formula (I') as defined above, and tautomeric and stereoisomeric forms th...
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