Calcium channel blocking drug molecule co-crystal and preparation method thereof

A calcium channel blocker and drug molecule technology, which is applied in the field of calcium channel blocker drug molecule co-crystals and its preparation, can solve the problems of drug stability being easily affected by the environment, and is suitable for large-scale application and improved solubility And the effects of stability and crystal form rules
CN110372576AInactive Publication Date: 2019-10-25FUDAN UNIV +1
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2019-10-25
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a calcium channel blocking drug molecule co-crystal and a preparation method thereof. The general molecular formula of the calcium channel blocking drug molecule co-crystal is(C20H25ClN2O5).(X).((CH3)2CHOH)n, wherein X represents one of benzene sulfonic acid, maleic acid and fumaric acid; and n represents the number of isopropanol molecules, and n is greater than 0 and less than and equal to 1. A co-crystal drug provided solves the solubility and stability problems of existing levamlodipine, and is beneficial to the improvement of the stability of levamlodipine tablets, preparation of the co-crystal is simple, the cost is low, the crystal form of the prepared crystal is regular, the particle size is uniform, and industrial production prospects are achieved.
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Description

technical field

[0001] The invention relates to the technical field of crystalline drugs, in particular to a calcium channel blocking drug molecular co-crystal and a preparation method thereof. Background technique

[0002] Amlodipine is a third-generation dihydropyridine calcium channel blocker, which is a potent and long-acting antihypertensive drug. Amlodipine is a racemic mixture of levamlodipine and dexamlodipine in a ratio of 1:1. Pharmacological studies have shown that the antihypertensive effect of levamlodipine is more than 1000 times that of dexamlodipine; Therefore, chiral split levamlodipine, as the fourth-generation calcium ion antagonist antihypertensive drug for the treatment of hypertension, is deeply trusted by doctors and patients due to its high efficacy and small side effects, and is currently a commonly used drug for the treatment of hypertension.

[0003] Due to the advantages of stability, reproducibility, bioavailability and operability, crystalline...

Claims

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