New crystalline type 3,4',5-trihydroxy stilbene-3-beta-D-glucocide
A technology of glucoside and trihydroxystilbene is applied in the field of 3,4',5-trihydroxystilbene-3-β-D-glucoside of new crystal form, which can solve the problems of double melting point and long melting range, and achieve Good compressibility, reduced raw material cost and easy quality control
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0033] [Example 1] Preparation of type II crystal form 3,4',5-trihydroxystilbene-3-β-D-glucoside
[0034] 3,4',5-trihydroxystilbene-3-β-D-glucoside (polydatin) raw material compound can be prepared by the method described in Chinese patent application 03117246; solvent ethanol and acetone are respectively re-distilled to obtain refined ethanol and refined acetone . Add 300g of polydatin to about 1L of refined ethanol solvent, dissolve and filter, concentrate the filtrate under reduced pressure (0.1Mpa, 55°C) to about 0.5L, add about 1L of refined acetone while it is hot, and place the mixed solution in a refrigerator at 4°C to precipitate a solid The product was vacuum-dried (0.1Mpa, room temperature) after suction filtration to obtain about 226g of type II polydatin.
[0035] Its XRD spectrum is as figure 1 As shown, the DSC spectrum is as figure 2 shown.
Embodiment 2
[0036] [Example 2] Preparation of Type III crystal form 3,4',5-trihydroxystilbene-3-β-D-glucoside
[0037] 3,4', 5-trihydroxystilbene-3-β-D-glucoside (polydatin) raw material compound can be prepared by the method described in Chinese patent application 03117246; solvent acetone, ethyl acetate, n-hexane are refined respectively to obtain refined Acetone, ethyl acetate and refined n-ethane. Add 100g of polydatin into about 1.5L of refined acetone solvent, dissolve and filter, concentrate the filtrate under reduced pressure (0.1Mpa, 55°C) to about 0.8L, add about 0.3L of refined ethyl acetate while it is hot, mix well, add Refined about 1 L of n-hexane, and placed the mixed solution in a refrigerator at 4°C. The precipitated solid was suction filtered and then vacuum-dried (0.1 Mpa, room temperature) to obtain about 69 g of type III polydatin.
[0038] Its XRD spectrum is as image 3 As shown, the DSC spectrum is as Figure 4 shown.
[0039] 0.5g of 3,4',5-trihydroxystilbene...
Embodiment 3
[0040] [embodiment 3] the preparation of solid pharmaceutical preparation
[0041] Element
[0042] Preparation method: The above prescription ingredients are mixed according to conventional preparation methods, and directly compressed into tablets.
[0043] Element
[0044] Preparation method: Type II crystal polydatin (Example 1) is mixed evenly with starch, lactose, and dextrin according to the method of equal multiplication, and the pre-prepared HPMC solution is added to make a soft material, granulated with a 20-mesh sieve, and dried at 60°C for about After 30 minutes, sieve with 18 meshes, add micropowder silica gel, mix evenly, and fill with 2# capsules.
[0045] Element
[0046] Preparation method: The above prescription ingredients are mixed, granulated and compressed into tablets according to conventional preparation methods.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com