New crystalline type 3,4',5-trihydroxy stilbene-3-beta-D-glucocide

A technology of glucoside and trihydroxystilbene is applied in the field of 3,4',5-trihydroxystilbene-3-β-D-glucoside of new crystal form, which can solve the problems of double melting point and long melting range, and achieve Good compressibility, reduced raw material cost and easy quality control
CN1903867AActive Publication Date: 2007-01-31SHENZHEN NEPTUNUS PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN NEPTUNUS PHARM CO LTD
Publication Date
2007-01-31

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Abstract

The present invention relates to two kinds of new crystal types of 3,4,5-resveratrol-3-beta-D-glucoside and their preparation method and medicine composition containing them.
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Description

technical field

[0001] The present invention relates to 3,4',5-trihydroxystilbene-3-β-D-glucoside (3,4',5-trihydroxy-stilbene-3-β-D-glucoside; polydatin) with a defined crystal form, As well as the preparation method of the crystal form and its application in pharmaceutical preparations. Background technique

[0002] literature Melting point (°C) crystallization solvent 1. Chinese patent (application number) 03117246 2. Fulvia Orsini. Isolation, Synthesis, and Antiplatelet Aggregation Activity of Resveratrol 3-O-β-D- Glucopyranoside and Related Compounds.J.Nat.Prod. 1997, 60, 1082~1087. (The reference cited in this article is Hillis WE, Ishikura K, J Chromatogr, 32, 323 (1968) has a melting point of 228-230 °C) 3. Gamini S. Jayatilake. Kinase Inhibitors From Polygonum Cuspidtum. Journal of Nature Products. 1993, 56(10), 1805-110. (References cited in this article M.Antoni, D.M.X. Donnelly, Phyto...

Claims

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