Immunogens used to prepare mprα monoclonal antibodies
A monoclonal antibody and immunogen technology, applied in the direction of anti-animal/human immunoglobulin, antibody, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, etc., can solve the problem of undeveloped targeted drugs, etc. problem, to achieve the effect of high price
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Embodiment 1
[0026] Design and preparation of embodiment 1mPRα monoclonal antibody
[0027] 1. Analysis and design of peptide sequences
[0028] Use DNAstar software to analyze the epitope of the amino acid of mPRα, evaluate its hydrophilicity, antigenicity, surface possibility, flexible region and other indexes, comprehensively consider the amino acid category, distribution, structural complexity, easy oxidation difficulty, synthesis difficulty, small Based on the homology between mice and humans, etc., the 18 amino acids at positions 297-314 of mPRα were finally determined as the sequence of the synthetic polypeptide, and the corresponding sequence was YEARRPIYEP LHTHWPHN. Such as figure 1 , mPRα has 7 transmembrane structures, and this polypeptide is located between the 6th and 7th transmembrane regions, covering the entire extramembrane segment. The ACT396 automatic multi-channel peptide synthesizer is used to automatically synthesize the target peptide according to the compiled prog...
Embodiment 2
[0041] Example 2 mPRα monoclonal antibody inhibits the ability of human sperm to respond to progesterone
[0042] The mPRα monoclonal antibody was prepared as in Example 1.
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