Colorectal cancer diagnosis kit

A colorectal cancer, kit technology, applied in biochemical equipment and methods, DNA/RNA fragment, microorganism determination/inspection, etc. The effect of reducing error rates and overcoming limitations
CN110387418AInactive Publication Date: 2019-10-29GUANGZHOU ZHONGYU BIOTECHNOLOGY CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU ZHONGYU BIOTECHNOLOGY CO LTD
Publication Date
2019-10-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of biotechnology, and particularly relates to a colorectal cancer diagnosis kit. The kit contains a reagent for detecting the methylation level of a to-be-detected sequence in a to-be-detected sample, and the to-be-detected sequence is located between an upstream 3.5kb sequence and a downstream 2kb sequence of an miR-17-92 cluster transcriptional start site. It is found for the first time that the low methylation level of an original cancer non-coding RNA miR-17-02 cluster in colorectal cancer is relevant to the generation and development of the colorectal cancer. The methylation level of the miR-17-92 cluster can be used as a biological indicator for tumor detection to assist diagnosis of the colorectal cancer, so that detection specificity and sensitivity are improved, the error rate is lowered, and the quite important clinic guidance significance to the tumor pathogenesis and diagnosis is achieved.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, in particular to a diagnostic kit for colorectal cancer. Background technique

[0002] Colorectal cancer (CRC) is one of the most common cancers in the world. The incidence of colorectal cancer in my country is about 14.2 / 100,000, showing a sharp upward trend in the past 20 years, and has become one of the fastest-rising malignant tumors. The occurrence of colorectal cancer must go through the normal mucosa, hyperplasia, adenoma formation, adenoma canceration, and the staged evolution of invasion and metastasis, and its development process can last for more than 10 years. Among them, adenomatous polyps are the most important precancerous lesions of colorectal cancer. Adenomatous polyps gradually increase in size and often take years to eventually become malignant. If colorectal cancer can be detected in the early stage, after surgical resection, the cure rate is very high, which can reach more tha...

Claims

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