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Composite nanomaterial and preparation method for early diagnosis and treatment of tumors

An early diagnosis and nanomaterial technology, applied in the field of biomedicine, can solve the problems of photobleaching, fluorescence quenching, complex preparation process, and low fluorescence yield of organic dyes, and achieve short synthesis time, simple preparation process, and good fluorescence imaging capabilities Effect

Active Publication Date: 2021-10-22
HUBEI UNIV OF TECH
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Problems solved by technology

Among them, quantum dots are biologically toxic, and the preparation process is complicated; the fluorescence yield of organic dyes is low (0.5% to 1.0%), and photobleaching is prone to produce fluorescence quenching

Method used

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  • Composite nanomaterial and preparation method for early diagnosis and treatment of tumors
  • Composite nanomaterial and preparation method for early diagnosis and treatment of tumors
  • Composite nanomaterial and preparation method for early diagnosis and treatment of tumors

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Embodiment Construction

[0028] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0029] Bi of the present invention 2 S 3 -AuNCs nanocomposites, including Bi 2 S 3NPs and AuNCs two materials. Utilizing the large amount of amino acids contained in BSA, Bi 3+ and Au 3+ Both can be combined with amino acid functional groups, such as: -SH, -NH 3 , -COOH, etc., combine to form BSA-Bi 3+ , BSA-Au 3+ ; by adjusting the pH to alkaline (~12), BSA exhibits a strong reducing ability to convert Bi 3+ and Au 3+ In situ reduction to Bi atoms and Au atoms to form Bi 2 S 3 NPs and AuNCs. The synthesized composite nanomaterials can not only realize the photothermal therapy guided by fluorescence-CT dual-mode imaging, but also Bi2S3 and AuNCs can achieve the effect of synergistic photothermal therapy.

[0030] The concrete process of preparation method of the present invention is as follows:

[0031] Utilize bovine se...

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Abstract

The invention discloses a composite nano material used for early diagnosis and treatment of tumors and a preparation method thereof. The novel nanomaterial is a composite of bismuth sulfide nanoparticles and gold nanoclusters. The preparation method is as follows: first, use bovine serum albumin (BSA) as a stabilizer and reducing agent to prepare bismuth sulfide nanoparticles (Bi 2 S 3 NPs), followed by the addition of chloroauric acid, Au 3+ In situ growth into gold nanoclusters (AuNCs) under alkaline conditions, and then bismuth sulfide-gold nanoclusters (Bi 2 S 3 ‑AuNCs) composites. Thanks Bi 2 S 3 With the functions of photothermal therapy and CT imaging, AuNCs has the ability of fluorescence imaging, AuNCs and Bi 2 S 3 NPs have photothermal therapy synergistic enhancement, and thus the formed complex can achieve better fluorescence imaging and CT imaging-guided photothermal therapy.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically refers to a composite nanomaterial used for early diagnosis and treatment of tumors and a preparation method thereof. Background technique [0002] Currently, the most effective way to reduce cancer mortality is early screening and diagnosis. Conventional early diagnosis methods include CT examination, X-ray examination, etc., but most of these methods have the disadvantages of low specificity and sensitivity. In recent years, early diagnosis based on fluorescent nanomaterials, such as quantum dots (QDs), organic dyes, and gold nanoclusters (AuNCs), has attracted widespread attention. Among them, quantum dots are biologically toxic, and the preparation process is complicated; the fluorescence yield of organic dyes is low (0.5%-1.0%), and photobleaching easily occurs to produce fluorescence quenching. Compared with quantum dots and organic dyes, gold nanoclusters not only have simple ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00A61K49/04A61K49/00C01G29/00
CPCA61K41/0052A61K49/0065A61K49/04A61P35/00C01G29/00
Inventor 孙红梅赵晓双
Owner HUBEI UNIV OF TECH
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