A Growth Factor Loaded Bacterial Cellulose/Bioceramic Composite Membrane

A technology of bacterial cellulose membrane and bacterial cellulose, which is applied in the field of growth factor-loaded bacterial cellulose/bioceramic composite membrane and its preparation, can solve the problem of growth factor easily inactivated loading capacity and release speed, bone repair bioceramic membrane machinery Poor strength, difficult to control and other problems, to achieve the effect of improving adhesion stability, improving permeability, and improving existence stability

Active Publication Date: 2022-03-29
东营凤起生物科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the deficiencies in the prior art, the purpose of the present invention is to provide a growth factor-loaded bacterial cellulose / bioceramic composite membrane, which has good biocompatibility and can effectively maintain the biological activity of bone repair growth factors, The repair material applied to bone defect tissue solves the problem of poor mechanical strength of bone repair bioceramic membranes; at the same time, the composite membrane can effectively control the release rate of growth factors, which solves the problem of easy growth factors in the current bone tissue repair materials loaded with growth factors. Deactivation and difficulty in controlling loading and release rates

Method used

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  • A Growth Factor Loaded Bacterial Cellulose/Bioceramic Composite Membrane
  • A Growth Factor Loaded Bacterial Cellulose/Bioceramic Composite Membrane
  • A Growth Factor Loaded Bacterial Cellulose/Bioceramic Composite Membrane

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Effect test

Embodiment 1

[0036]A bacterial cellulose membrane / bioceramic composite membrane loaded with growth factors is characterized in that the composite membrane is based on the bacterial cellulose membrane, and the surface is loaded with growth factors in the form of gel deposition coating, and then It is obtained by carrying a bioceramic film on its surface by electrospinning technology; its preparation method includes the following steps:

[0037] (1) Preparation of bacterial cellulose membrane loaded with growth factors

[0038] Inoculate the activated strain of Acetobacter xylinum into the egg liquid fermentation medium, take out the bacterial cellulose membrane on the upper layer of the fermentation broth after 4-5 days of fermentation, wash with warm water after washing until the washing liquid is neutral, and remove the bacterial cellulose membrane Cut to a size of 2cm×2cm, ready for use; Among them, the egg liquid medium is a fermentation medium obtained by adding 40g of sucrose, 15g of ...

Embodiment 2

[0046] A bacterial cellulose membrane / bioceramic composite membrane loaded with growth factors is characterized in that the composite membrane is based on the bacterial cellulose membrane, and the surface is loaded with growth factors in the form of gel deposition coating, and then It is obtained by carrying a bioceramic film on its surface by electrospinning technology; its preparation method includes the following steps:

[0047] (1) Preparation of bacterial cellulose membrane loaded with growth factors

[0048] Inoculate the activated strain of Acetobacter xylinum into the egg liquid fermentation medium, take out the bacterial cellulose membrane on the upper layer of the fermentation broth after 4-5 days of fermentation, wash with warm water after washing until the washing liquid is neutral, and remove the bacterial cellulose membrane Cut to a size of 4cm×4cm, ready for use; Among them, the egg liquid medium is a fermentation medium obtained by adding 40g of sucrose, 15g of...

Embodiment 3

[0056] A bacterial cellulose / bioceramic composite membrane loaded with growth factors is characterized in that the composite membrane is based on the bacterial cellulose membrane, and the surface is loaded with growth factors in the form of gel deposition coating, and then electrostatic Spinning technology is obtained by loading bioceramic membrane on its surface; its preparation method includes the following steps:

[0057] (1) Preparation of bacterial cellulose membrane loaded with growth factors

[0058] Inoculate the activated strain of Acetobacter xylinum into the egg liquid fermentation medium, take out the bacterial cellulose membrane on the upper layer of the fermentation broth after 4-5 days of fermentation, wash with warm water after washing until the washing liquid is neutral, and remove the bacterial cellulose membrane Cut to a size of 5cm×5cm, ready for use; Among them, the egg liquid medium is a fermentation medium obtained by adding 40g of sucrose, 15g of agar, ...

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Abstract

The invention discloses a bacterial cellulose / biological ceramic composite membrane loaded with growth factors and a preparation method thereof. The composite membrane is based on bacterial cellulose membrane, and is loaded with growth factors on its surface in the form of gel deposition coating, and then It is obtained by coating the bioceramic membrane on its surface by electrospinning technology; both the bacterial cellulose membrane and the bioceramic membrane have a nanofiber structure, which is used as a tissue repair material and has sufficient contact space with the cell environment of the damaged tissue; at the same time, It has a good effect of maintaining the activity of growth factors, and can control the release rate of growth factors by controlling the degradation rate of the composite membrane, and has good application value in tissue repair such as promoting tissue division and cell regeneration.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a bacterial cellulose / biological ceramic composite membrane loaded with growth factors and a preparation method thereof. Background technique [0002] Bone defect caused by trauma, tumor, etc. has become a common clinical disease at present. At present, the use of tissue engineering to repair bone defect has become a hot spot, and the tissue engineering scaffold materials used for bone tissue defect repair are mostly concentrated in the use of biopolymers. Composites of materials and ceramic particles, but simple composite materials have the problem of low biological activity. It is one of the research directions of tissue engineering to obtain higher activity of composite tissue engineering materials by loading growth factors; [0003] At present, tissue repair materials loaded with growth factors have been extensively studied. Growth factor loading can regulate the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61L27/20A61L27/34A61L27/54A61L27/46A61L27/56A61L27/22A61L27/58
CPCA61L27/20A61L27/34A61L27/54A61L27/46A61L27/56A61L27/22A61L27/58A61L2300/252A61L2300/414A61L2300/604A61L2300/606C08L1/02C08L67/04
Inventor 张正男段书霞韩涵付迎坤林建香石沛龙崔彬彬王红磊韩修恒田崇于肇锦郝明严子跃佘开江
Owner 东营凤起生物科技发展有限公司
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