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Liquid capsule for microfluidic chip

A microfluidic chip and liquid capsule technology, which is applied to laboratory containers, laboratory utensils, chemical instruments and methods, etc., can solve the problems of unfavorable miniaturization of microfluidic chips

Pending Publication Date: 2019-11-29
YANTAI JIEZI BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in order to move the bag capsule and the cavity wall relatively during centrifugation, the cavity needs to have a large enough space, which is obviously not conducive to the miniaturization of the microfluidic chip.

Method used

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  • Liquid capsule for microfluidic chip
  • Liquid capsule for microfluidic chip
  • Liquid capsule for microfluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Polypropylene (PP) is used to make multiple identical liquid capsules, and the aluminum foil film is sealed with a heat sealer at the sealing part (the distal end). The aluminum foil film has a double-layer structure, one layer is PP film, and the other layer is aluminum foil for support. Under the condition of heating, the PP film melts and bonds with other parts of the sac membrane. By controlling the heat sealing temperature, pressure and time to achieve consistent heat sealing tightness on the sealing plane. Different volumes of liquid are respectively enclosed in these liquid pockets. Divided into two groups, in which the fluid capsule group 1 only contained liquid, and fluid capsule group 2 added a steel ball to assist fluid release. The liquid capsules are respectively placed in the cavities of the microfluidic chip, and centrifuged in a centrifuge. The results are shown in Table 1. After centrifugation at 1200rpm for 30 seconds, the liquid in the liquid sac gr...

Embodiment 2

[0053] Use polypropylene (PP) to make two identical liquid capsules, and seal the aluminum foil film with a heat sealer at the sealing point (distal end). Both blocked 500 microliters of liquid. Wherein the liquid capsule A only includes liquid, and the liquid capsule B also has a conical steel piercing structure. The shape of the sac and punctured structure is as figure 2 shown. The liquid sacs A and B are respectively placed in the cavity of the microfluidic chip, and centrifuged in a centrifuge. After centrifuging at 1000rpm for 30 seconds, the liquid in the liquid sac B is released, and the structure of the liquid sac A is still intact. The liquid in the liquid sac A cannot be released until it is centrifuged at 2000 rpm for 30 seconds.

Embodiment 3

[0055] Use polypropylene (PP) to make two identical liquid capsules, and seal the aluminum foil film with a heat sealer at the sealing point (distal end). Block with 400 µl of liquid. Wherein the liquid sac A includes steel balls with a diameter of 1 mm and 400 microliters of liquid, and the liquid sac B includes a steel column of 1 mm×1 mm×4 mm and 400 microliters of liquid. The liquid capsules A and B were respectively placed in parallel chambers of the same microfluidic chip, and centrifuged in a centrifuge. After centrifuging at 600rpm for 30 seconds, the liquid in sac B is released, and the structure of sac A is still intact. Then increase the rotational speed, continue to centrifuge at 1200 rpm for 30 seconds, and the liquid in the liquid sac A is released.

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Abstract

The invention provides a liquid capsule for storing and releasing a liquid in a microfluidic chip, wherein the liquid capsule comprises a liquid capsule film forming a sealed space, a liquid in the sealed space and a puncture structure, wherein the puncture structure can puncture the liquid capsule film under the drive of a centrifugal force, so that the liquid is released from the liquid capsule.The invention also provides the microfluidic chip comprising one or more of the liquid capsules. The liquid capsule is an independent structure, can be placed in any cavity of the microfluidic chip,utilizes the centrifugal force to drive the puncture structure to release the liquid, the liquid capsule and the microfluidic chip do not need to be physically welded, an extra mechanical structure does not need to be used for applying a mechanical force to destroy the structure of the liquid capsule, and the microfluidic chip is particularly suitable for automatic operation.

Description

technical field [0001] The invention relates to a liquid capsule for a microfluidic chip, in particular to a liquid capsule capable of controlling the release of liquid in the liquid capsule through centrifugal force. Background technique [0002] Microfluidic technology has been widely used in biological, chemical, and medical analysis. It can concentrate the operations of sample preparation, separation, reaction, and detection on a micron-scale platform, that is, a microfluidic chip. Microfluidic analysis systems generally include three parts: microfluidic chips, detection reagents and supporting detection instruments. The design of a microfluidic chip requires the use of microfabrication technology to integrate microchannels, microreaction chambers and microvalve components to complete sample pretreatment, sample distribution, sample quantification, mixing and reaction of samples and reaction reagents, and reaction on the chip. Functions such as the detection of results ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027
Inventor 张屹
Owner YANTAI JIEZI BIOTECHNOLOGY CO LTD