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Molecular marker for preventing, diagnosing and treating tongue squamous cell carcinoma, and application thereof

A technique for molecular markers and tongue squamous cell carcinoma, applied in the fields of molecular biology and biomedicine

Active Publication Date: 2019-12-27
HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no relevant reports on the expression of DANCR in tongue squamous cell carcinoma in the prior art, but finding effective early onset biomarkers and related molecular mechanisms is of great significance to guide the clinical diagnosis, treatment and prognosis of tongue squamous cell carcinoma

Method used

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  • Molecular marker for preventing, diagnosing and treating tongue squamous cell carcinoma, and application thereof
  • Molecular marker for preventing, diagnosing and treating tongue squamous cell carcinoma, and application thereof
  • Molecular marker for preventing, diagnosing and treating tongue squamous cell carcinoma, and application thereof

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Embodiment Construction

[0057] The specific implementation manners of the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. The following examples are used to illustrate the present invention, but these examples are only for illustrating the present invention, and the present invention is not limited to these contents. The operating methods not specifically described in the examples are conventional operating methods in the technical field.

[0058] Example.

[0059] 1. Cell Culture and Reagents.

[0060] Four human TSCC cell lines SCC9, TSCCA, TCa-8113 and CAL-27 cells were used in this experiment. SCC9 cells (Cellcook, Guangzhou) were cultured in DMEM / F12 medium supplemented with 10% fetal bovine serum (SH30084.03, Hyclone, South Logan, UT, USA); TSCCA cells (Procell, Wuhan) were cultured in 10% fetal bovine serum Serum in DMEM medium (12100-46, Gibco); TCa-8113 and CAL-27 cell lines (Procell, Wuhan) were cultured in RPMI-1...

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Abstract

The present invention relates to the technical fields of molecular biology and biomedicine, and particularly relates to a molecular marker for preventing, diagnosing and treating tongue squamous cellcarcinoma, and an application thereof. The disclosed molecular marker for preventing, diagnosing and treating the tongue squamous cell carcinoma is LncRNA DANCR. The molecular marker is applied in screening or preparing reagents for diagnosing tongue squamous cell carcinoma and screening or preparing medicines for treating tongue squamous cell carcinoma. The LncRNA DANCR is found to be highly expressed in tongue squamous cell carcinoma tissues and an independent indicator for diagnosing tongue squamous cell carcinoma and judging progression and survival prognosis of tongue squamous cell carcinoma. Besides, silencing LncRNA DANCR can inhibit proliferation, cell migration and invasion of tongue squamous cell carcinoma in vitro. The LncRNA DANCR is confirmed for the first time as an importantoncogenic factor for tongue squamous cell carcinoma and can be used as the molecular marker for tongue squamous cell carcinoma diagnosis and a new target for treatment.

Description

technical field [0001] The invention relates to the technical fields of molecular biology and biomedicine, in particular to a molecular marker for the prevention, diagnosis and treatment of squamous cell carcinoma of the tongue and its application. Background technique [0002] Tongue squamous cell carcinoma (TSCC) is the main type of head and neck squamous cell carcinoma (HNSCC), with high recurrence rate, high metastasis rate and poor prognosis. Despite significant advances in prevention and treatment, the survival rate of TSCC patients remains poor. The results showed that tumor invasion and migration were the main reasons for tumor development. Therefore, it is imminent to develop new therapeutic strategies by exploring the underlying molecular mechanisms of TSCC. [0003] Long noncoding RNA (long noncoding RNA, lncRNA) is a group of long noncoding RNAs with a length of more than 200 nucleotides. A large number of reports have shown that lncRNAs play an important role...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113A61K45/00A61K31/713A61P35/00
CPCC12Q1/6886A61K45/00A61K31/713A61P35/00C12Q2600/158C12Q2600/178C12Q2600/136
Inventor 郑颖刘奕郑博文安娜刘帆时逸贡雨嘉刘崇良
Owner HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV
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