A microfluidic printing chip and design method thereof

Abstract

The invention discloses a microfluidic printing chip and a design method thereof, and relates to the technical field of laboratory precision liquid volume measurement and biochemical analysis instruments. The invention includes an elastic layer, a structural encapsulation layer, and an encapsulation chip encapsulated in the elastic layer and the structural encapsulation layer; the encapsulation chip includes a liquid storage cavity, and the liquid storage cavity is connected with an impact cavity through a rear-end micropipe with an expansion angle, and the impact cavity A spout is communicated with through the micro-pipe at the front end. The present invention introduces a back-end micro-pipe with an expansion angle, which can effectively reduce the amount of air sucked back during the printing process, increase the stability of printing, increase the highest frequency of stable printing of droplets, and achieve the highest resolution of 0.1 nanoliters. It also improves the service life of the chip. A chip stored full of liquid can distribute tens of thousands of uniform volume droplets without external liquid supply at one time; at the same time, micro-volume droplets are continuously generated to quantitatively obtain the required volume of liquid, and the air is sucked back Less, stable printing.

Description

technical field [0001] The invention belongs to the technical field of laboratory precision liquid volume measurement and biochemical analysis instruments, and in particular relates to a microfluidic printing chip and a design method thereof. Background technique [0002] In the experiments of chemistry, biology and other disciplines, it is often necessary to operate the solution for quantitative sample addition. For the operation of liquids in microliter and submicroliter volumes, it is generally realized by pneumatic or printing methods. Current products include: Mosquito series from TTP Labtech, D300e digital dispenser from Tecan, etc. The traditional droplet distribution method mainly depends on adjusting the size of the nozzle to adjust the droplet size. Therefore, in order to obtain smaller volume droplets, such as nanoliters to picoliters, it is necessary to use very small nozzles and precise drive control. Such as Sharp Corporation's patent CN200780048206.X. This ...

AI Technical Summary

Problems solved by technology

However, the design principle of the pipeline is not yet clear

On the other hand, in the process of microfluidic printing to generate droplets, there is an air back-suction phenomenon, and air back-suction will affect the stability of droplet generation, and even interrupt droplet printing.

Not only that, but the suck-back of air can also affect the time for the pipe to refill the liquid, thus reducing the frequency of printing

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