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Black sea bream antibacterial peptide AS-hepc3 (48-56) and application thereof

一种抗菌肽、C48H86N24O10S3的技术，应用在抗细菌药、肽/蛋白质成分、肽等方向，能够解决多重耐药性耐药性、单一等问题，达到不易耐药性、好应用前景、易合成的效果

Active Publication Date: 2020-02-11
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the clinical isolation of drug-resistant bacteria, not only single drug-resistant strains, but also multi-drug resistant, extremely high drug-resistant and completely drug-resistant bacteria were found, which brought great challenges to clinical treatment

Method used

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  • Black sea bream antibacterial peptide AS-hepc3 (48-56) and application thereof
  • Black sea bream antibacterial peptide AS-hepc3 (48-56) and application thereof
  • Black sea bream antibacterial peptide AS-hepc3 (48-56) and application thereof

Examples

Experimental program
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Embodiment 1

[0019] A black sea bream antibacterial polypeptide AS-hepc3 of this embodiment (48-56) The amino acid sequence of is:

[0020] Arg-Arg-Arg–Arg–Cys-Arg-Phe–Cys-Cys (SEQ ID NO: 01)

[0021] In this example, Jill Biochemical (Shanghai) Co., Ltd. was entrusted to synthesize the black sea bream antibacterial polypeptide AS-hepc3 with a purity of more than 95% by solid-phase synthesis. (48-56) , And provide detection information such as peptide molecular weight and HPLC. The relevant physical and chemical parameters are shown in Table 1.

[0022] Table 1 Antibacterial peptide AS-hepc3 (48-56) Physical and chemical parameters

[0023]

[0024] It can be seen from Table 1 that the black sea bream antibacterial polypeptide AS-hepc3 of this embodiment (48-56) It has a small molecular weight, good stability, and strong water solubility. It is a positively charged cationic polypeptide.

[0025] 1. Determination of Minimum Inhibition Concentration (MIC: Minimum Inhibition Concentration) and Minimum ...

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Abstract

The invention discloses a black sea bream antibacterial peptide AS-hepc3 (48-56) and application thereof. The molecular formula of the black sea bream antibacterial peptide AS-hepc3 (48-56) is C48H86N24O10S3, and the amino acid sequence of the black sea bream antibacterial peptide AS-hepc3 (48-56) is SEQ ID NO: 01. The antibacterial peptide AS-hepc3 (48-56) disclosed by the invention is applied asan effective component of an antibacterial drug, has the characteristics of small length, high antibacterial activity, difficulty in generating drug resistance, capability of resisting various clinical drug-resistant bacteria and the like, and has a wide prospect in the aspect of research and development of drugs for resisting drug-resistant bacteria.

Description

Technical field [0001] The invention belongs to the technical field of marine molecular biology, and specifically relates to a black sea bream antibacterial peptide AS-hepc3 (48-56) And its application. Background technique [0002] In 1928, British scientist Fleming discovered the first antibiotic-penicillin. Since then, antibiotics have been continuously discovered, improved and used in modern medicine. With the widespread use of antibiotics, antibiotic resistance is constantly being discovered. The World Health Organization's 2014 report proposed that antibiotic-resistant bacteria have spread globally, and we have entered the post-antibiotic era. At present, there are reports of antibiotic resistance worldwide, which has become one of the important issues that need to be solved urgently in the world. The WHO pointed out that at least 700,000 people die from drug-resistant diseases every year, and if effective measures are not taken, this number will reach 10 million in 2050....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/46A61K38/17A61P31/04
CPCC07K14/461A61P31/04A61K38/00Y02A50/30C07K7/06
Inventor 王克坚朱德鹏彭会陈芳奕陈慧芸
Owner XIAMEN UNIV
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